芪丹化瘀方治疗缺血性卒中急性期气虚血瘀证的临床效果观察  

Clinical effect of Qidan Huayu Fang on acute ischemic stroke

作　　者：程广清[1] 杨晓妮[1] 陈超[1] 李长生[1] 

机构地区：[1]山东省千佛山医院中医科,济南250014

出　　处：《中国医药》2014年第10期1461-1463,共3页China Medicine

基　　金：山东省自然科学基金（Y2005C43）;山东省中医药科技发展计划（2011-192、2013ZDZK-091）

摘　　要：目的 探讨芪丹化瘀方对气虚血瘀证急性期缺血性卒中的临床疗效和机制.方法 将60例气虚血瘀证急性期缺血性卒中患者,按随机数字表法分为芪丹化瘀组30例,脑心通组30例.在常规治疗基础上,芪丹化瘀组患者应用芪丹化瘀方,脑心通组加用步长脑心通胶囊,均治疗21d,观察2组中医气虚血瘀证证候积分以及神经缺损评分的变化,检测2组脑血流动力学指标,同时进行安全性分析.结果 2组治疗后,芪丹化瘀组总有效率、神经功能缺损评分、中医证候积分改善程度,均优于脑心通组治疗后,差异有统计学意义[86.7％（26/30）比73.3％ （22/30）;（7±3）分比（10±5）分;气虚证：（7.0±2.5）分比（9.1±3.2）分;血瘀证：（8.0±3.1）分比（9.5±3.1）分,P＜0.05或P＜0.01];治疗后脑血流速度较治疗前均有明显改善,与脑心通组治疗后比较,差异有统计学意义（P＜0.05或P＜0.01）.结论 芪丹化瘀方对缺血性卒中急性期气虚血瘀证具有较好的治疗效果.Objective To study the clinical effect of Qidan Huayu Fang on acute ischemic stroke.Methods Totally 60 cases of patients with acute ischemic stroke （qi deficiency and blood stasis syndrome） were randomly （random number table） divided into Qidan Huayu Group （n =30） and Naoxintong Group （n =30）.In addition to regular treatment,Qidan Huayu Group was given Qidan Huayu Fang,and Naoxintong Group was given Naoxintong Capsule.All the patients were treated for 21d.TCM syndrome scores and nerve defects scores were observed.Cerebral hemodynamic indexes of the two groups were compared.Safety analysis was also perforoed.Results After treatment,Qidan Huayu Group was better than Naoxintong Group in total effective rate,neural function defect scores and improvement of TCM syndrome scores,and the difference were statistically significant [86.7% （26/ 30） vs.73.3% （22/30）,（7 ±.3） points vs.（10 ±5） points; Qi deficiency syndrome：（7.0 ±2.5） points vs.（9.1 ±3.2） points; bloodstasis：（8.0±3.1） points vs.（9.5 ±3.1） points,P〈0.05 or P〈0.01].After treatment,cerebral bloodflow velocity was obviously improved than before treatment.Compared with Naoxintong Group,the difference was statistically significant （P 〈 0.05 or P 〈 0.01）.Conclusion Qidan Huayu Fang has relatively good therapeutic effects on acute ischemic stroke （qi deficiency and blood stasis syndrome）.

关 键 词：脑血管病症 缺血性卒中 芪丹化瘀方 临床观察 

分 类 号：R743.3[医药卫生—神经病学与精神病学]