轻度阿尔茨海默病的汉语假词阅读研究  

Pseudo-words reading of Chinese patients with mild Alzheimer＆#39;s disease

作　　者：李放[1] 苏卫红[1] 陈雨[1] 王青[1] 

机构地区：[1]首都医科大学附属复兴医院,北京100038

出　　处：《中华行为医学与脑科学杂志》2014年第9期805-807,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：北京市西城区优秀人才培养资助2011QRC0349

摘　　要：目的 分析AD患者在语义加工过程中由形到音、以及由音到义这两个步骤损害的差异及其特征.方法 假词测验内容包括2部分：假-真词、假-假词,每组各10个.20个词随机呈现,分别记录每个词阅读正确数（代表形→音）与判断正确数（代表音→义）,正确得1分,错误或不知道得0分.每组总分为20分.结果 41例轻度AD和135名正常对照组被试在年龄、性别和教育程度上差异无统计学意义,MMSE总分分别为（21.06±2.86）分和（28.08± 1.52）分.正常老人组和轻度AD组,假-真词、假-假词“形→音”阅读正确数与“音→义”判断正确数无显著相关性（P＞0.05）.正常老人和轻度AD组的假词测验表现比较：在“形→音”阶段,正常老人和轻度AD组的假词阅读差异无统计学意义（P＞0.05）,在“音→义”阶段,假-真词判断正确数在两组间差异有统计学意义（P＜0.01）,而假-假词在两组间差异无统计学意义（P＞0.05）.结论 轻度AD患者存在“音→义”联络通路的损害.Objective To analyze the language function impairment differences between the two steps from the form to sound processing and from the sound to meaning processing for pseudo-words reading in Alzheimer＇s disease （AD）.Methods The pseudo-words reading test consists two parts：pseudo-true words and pseudopseudo words.Each part had 10 words.All of the 20 words were presented randomly.Correct reading presents the processing of from form to sound,and correct judging presents the processing of from sound to meaning.Each correct respond get 1 score,otherwise get 0.Each part had a total score of 20.Results The pseudo-words reading test was performed to 41 mild AD participants with Mini-mental State Examination （MMSE） average scores of （21.06 ±2.86）,and 135 normal controls with MMSE average scores of （28.08± 1.52）.The two groups were matched in age,gender and education.For all of the mild AD group and normal control group,there was no significant difference between reading score and judging score in either pseudo-true words or pseudo-pseudo words （P〉0.05）.Comparing with mild AD group and normal control group,there was no significant difference in reading score in either pseudo-true words or pseudo-pseudo words （P〉0.05）.For judging score,there was significant difference in pseudotrue words （P〈0.01） but not in pseudo-pseudo words （P〉0.05）.Conclusion Understanding real syllable is impaired in patients with mild AD.

关 键 词：假词 阅读 阿尔茨海默病 

分 类 号：R749.16[医药卫生—神经病学与精神病学]