Prame 基因在血液恶性肿瘤中的表达与治疗  

Expression and therapy of Prame gene on hematologic malignancies

作　　者：刘召云[1] 

机构地区：[1]天津医科大学研究生院,700030

出　　处：《国际肿瘤学杂志》2014年第8期611-614,共4页Journal of International Oncology

摘　　要：黑色素瘤特异性抗原作为肿瘤睾丸抗原家族成员之一，通过抑制维甲酸受体信号通路，阻碍调控细胞生长、分化的转录因子，促进肿瘤的形成。其在实体肿瘤及血液恶性肿瘤中均有表达，因此多用于肿瘤的诊断、转移监测及免疫细胞治疗。As a member of the family of cancertestis antigen,preferentially expressed antigen of mela-noma（Prame）can improve the proliferation of tumor via inhibiting the retinoic acid receptor signal path and impeding the transcription factor which is a wide range of physiological processes in development and differentiation of tumor cells. Prame expresses in solid tumors and hematological malignancies,which is widely used for tumor diagnosis,monitoring of tumor metastasis and immunotherapy.

关 键 词：血液肿瘤 免疫疗法 黑色素瘤特异性抗原 

分 类 号：R733[医药卫生—肿瘤]