^(99m)Tc-HL91乏氧显像在恶性脑胶质瘤放疗前后的变化观察  

Observation of ^(99m)Tc-HL91 Lack Oxygen Imaging Changes before and after Radiotherapy for Malignant Gliomas

作　　者：董方[1,2] 薛金才[1,2] 王小虎[1,2] 

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]甘肃省肿瘤医院,兰州730050

出　　处：《肿瘤预防与治疗》2014年第4期185-189,共5页Journal of Cancer Control And Treatment

基　　金："甘肃省技术研究与开发专项计划"经费资助

摘　　要：目的:观察并分析恶性脑胶质瘤术后患者放疗前、后99mTc-HL91 SPECT脑乏氧显像T/N比值的变化差异性及变化趋势,比较单纯术后放疗的Ⅱ级脑胶质细胞瘤患者放疗前后乏氧显像T/N比值差值与放疗后6个月疗效之间的相关性。方法:对35例恶性脑胶质瘤术后患者,分别于放疗前、后进行99mTc-HL91 SPECT脑乏氧显像检测,测定早期相(0.5小时)及延迟相(5个小时)的肿瘤区与周围正常脑组织放射性计数比值T/N,将检测结果进行差异性比较。筛选出其中13例Ⅱ级脑胶质瘤患者,以RECIST标准对比MRI资料评价放疗疗效,比较放疗前后T/N差值与疗效的相关性。结果:Ⅱ级脑胶质瘤术后患者乏氧显像早期相T/N比值均数值放疗后高于放疗前,差异有统计学意义(p<0.05)。Ⅱ级脑胶质瘤术后患者乏氧显像延迟相T/N比值均数值放疗后低于放疗前,差异有统计学意义(p<0.05)。Ⅲ级及Ⅱ-Ⅳ级脑胶质瘤术后患者乏氧显像延迟相T/N比值均数值放疗后低于放疗前,差异有统计学意义(p<0.05)。Ⅱ级脑胶质细胞瘤放疗前、后99mTc-HL91 SPECT脑乏氧显像延迟相(5小时)T/N比值差值与放疗后6个月疗效呈正相关,有统计学意义(r=0.635,p=0.020)。所有患者检测过程中均无任何严重毒副作用。结论:Ⅱ级恶性脑胶质瘤术后患者放疗前后99mTc-HL91 SPECT脑乏氧显像适用于短期放疗疗效的评价。objective：To observe and analyze the change tendency of T/N ratio of 99m Tc-HL91 SPECT lack oxygen imaging before and after radiotherapy for postoperative patients with malignant glioma . For patients with gradeⅡbrain glio-ma who were treated with simple postoperative radiotherapy ,the correlation between the change of T/N ratio before and af-ter radiotherapy and the curative efficacy 6 months after radiotherapy was evaluated. Methods：Thirty-five cases of postop-erative patients with malignant glioma received 99m Tc-HL91 SPECT cerebral lack oxygen imaging examination before and after radiotherapy. The radioactive count ratio T/N of tumor tissue VS. the normal brain tissue around the tumor area in the early phase （0. 5 hour） and delayed phase （5 hours） was detected. The test results were compared. For the 13 patients with grade Ⅱ glioma, the efficacy of radiotherapy was evaluated according to the results of the MRI with RECIST stand-ards. The correlation between the variation of T/N before and after radiotherapy and the radiotherapy efficacy was studied. Results： The early phase T/N ratio of lack oxygen postoperative imaging of grade Ⅱ glioma patients was significantly higher after radiotherapy than that before radio-therapy （p〈0. 05）, while the late phase T/N ratio was lower after radiotherapy than that before radiotherapy （ p〈0. 05 ） . T/N ratio in delayed phase of levelsⅢandⅡ-Ⅳpostoper-ative patients with glioma after radiotherapy were lower than that before radiotherapy with significant difference （ p 〈0. 05） . For postoperative patients with grade Ⅱmalignant glioma , the changing of T/N ratio in delayed phase before and after radiotherapy was positively correlated with the radiotherapy curative efficacy after 6 months （r=0. 635,p=0. 020）. No serious side effects were observed during the whole process of testing. Conclusion：For patients with grade II brain glio-ma, 99m Tc-HL91 SPECT cerebral lack oxygen imaging examination may be helpful for the evaluation of

关 键 词：乏氧显像 恶性脑胶质细胞瘤 放射治疗 

分 类 号：R739.41[医药卫生—肿瘤] R730.55[医药卫生—临床医学]