参附注射液用于减轻肿瘤化学疗法不良反应的系统评价  

Systematic Review on Shenfu Injection in Reducing Adverse Toxicity of Chemotherapy

作　　者：肖雄[1] 李姝[2] 吴侦侦 李廷谦[2] 

机构地区：[1]成都市第五人民医院中西医结合科,成都611130 [2]四川大学华西医院中西医结合科

出　　处：《华西医学》2014年第9期1659-1669,共11页West China Medical Journal

摘　　要：目的评价参附注射液减轻肿瘤患者化学疗法(化疗)的不良反应的疗效。方法检索Medline、PubMed、Embase、维普数据库、中文科技期刊全文数据库、中国期刊全文数据库、中国生物医学文献数据库、万方数据库,检索时间均为1994年1月-2013年5月,检索使用参附注射液配合化疗减轻化疗不良反应的临床随机对照试验,无语种限制。纳入文献的质量采用Jadad评分表评价。对纳入的试验进行系统评价。结果共纳入30篇文献,均为中文文献,共2 039例患者。参附注射液配合化疗(参附组)与单纯化疗组比较,参附组化疗后白细胞计数正常率较单纯化疗组高,差异有统计学意义[RR=1.54,95%CI(1.28,1.84),P<0.000 01];参附组化疗后血红蛋白正常率较单纯化疗组高,差异有统计学意义[RR=1.30,95%CI(1.14,1.48),P<0.000 1];参附组化疗后血小板计数正常率较单纯化疗组高,差异有统计学意义[RR=1.39,95%CI(1.19,1.62),P<0.000 1];参附组无恶心呕吐的患者比例高于单纯化疗组,差异有统计学意义[RR=1.54,95%CI(1.30,1.81),P<0.000 01];参附组生活质量评分明显优于单纯化疗组。结论参附注射液配合化疗与单纯化疗相比,可减轻外周血细胞的减少、胃肠道反应,提高患者生活质量。由于所纳入试验的方法学质量普遍较低,目前尚不能就此得出结论,需要设计更加合理、严格执行的大样本随机试验。Objective To evaluate the clinical efficacy of shenfu injection in reducing the side effects of chemotherapy in patients with cancer. Methods We searched Medline, PubMed, EMbase, VIP, Chinese science and technology periodical database full text database, China journal full database, Chinese biomedical literature database, and WANFANG database the durationi was from January 1994 to May 2013 for controlled trials about the use of shenfu injection to reduce the side effects of chemotherapy, without any language limitations. The quality of literature was evaluated by Jadad rating scale, and the included trials were analyze for systematic review. Results A total of 30 articles were included, and all of them were from Chinese literature. There were altogether 2039 cases. Compared with single chemotherapy group, the normal rate of white blood cells [RR=1.54, 95%CI （1.28, 1.84）, P 〈 0.0000 1], hemoglobin [RR--1.30, 95%CI （1.14, 1.48）, P 〈 0.000 1], platelet [RR=1.39, 95%CI （1.19, 1.62）, P 〈 0.000 1], and the number of patients without vomiting or sickness [RR=1.54, 95%CI （1.30, 1.81）, P 〈 0.0000 1] in the shenfu treatment group were all significantly higher. The life quality of the shenfu treatment group was also obviously better than the single chemotherapy group. Conclusions Compared with single chemotherapy, shenfu injection can reduce the peripheral blood cell reduction, gastrointestinal reaction and improve the patients＇ quality of life. Because the quality of included studies in this research is generally low, it is necessary to design a more reasonable and strict experiment with a large sample to get an exact conclusion.

关 键 词：参附注射液 化学疗法 不良反应 

分 类 号：R730.53[医药卫生—肿瘤]