石家庄地区生育障碍者的细胞遗传学分析  

Cytogenetic Analysis of Reproductive Disorder Patients in Shijiazhuang Area

作　　者：彭园园[1] 赵丽娟[1] 高虹[1] 孙东兰[1] 米冬青[1] 张艳华[1] 

机构地区：[1]石家庄市第四医院产前诊断中心,石家庄050011

出　　处：《生殖与避孕》2014年第9期742-748,共7页Reproduction and Contraception

摘　　要：目的:探讨石家庄地区生育障碍者的染色体异常状况,了解不同疾病与异常核型间的关系。方法:收集石家庄地区生育障碍者的外周血淋巴细胞进行培养,制片,G显带,行染色体核型分析。结果:收集到的3 558例生殖障碍者中,共检出染色体核型异常327例,包括数目和结构异常166例,染色体多态161例,异常率为9.19%。其中1 347对(2 694例)不良孕产史夫妇的染色体异常检出率为6.27%,769例男性不育患者的染色体异常检出率为19.12%,95例闭经/性腺发育不良患者的染色体异常检出率为11.58%。结论:染色体异常是导致反复流产、生育畸形儿、原发闭经、性腺发育异常等生育障碍的重要原因之一,进行染色体检查有助于患者的临床诊断与治疗。Objective： To investigate the relationship between chromosome abnormality and patients with different reproductive disorders. Methods： Patients with reproductive disorders in Shijiazhuang area were collected. G banding techniques were used by regular culturing lymphocytes of peripheral blood, then the chromosome karyotypes were analyzed. Results： There were 327 cases of abnormal karyotypes in 3 558 patients with reproductive disorder. The abnormality rate was 9.19%. The abnormality rates of abnormal pregnancy history group （1 347 couples）, male infertility group （769 cases） and amenorrhea/abnormal gonadal development group （95 cases） were 6.27%, 19.12% and 11.58%, respectively. Conclusion： Chromosomal abnormality is one of the important reasons for the habitual abortion, child deformity, primary amenorrhea and infertility, etc. Chromo- some karyotyping is necessary for clinical diagnosis and treatment of such patients. It can provide an important basis for fertility guidance, which will decrease the birth defect rate and improve population quality.

关 键 词：不良孕产史 自然流产 不育 闭经 染色体 

分 类 号：R711.6[医药卫生—妇产科学]