尼莫地平联合依达拉奉治疗高血压脑出血的Meta分析  

Efficacy of nimodipine combined with edaravone in treatment of hypertensive intracerebral hemorrhage:a meta-analysis

作　　者：陈谦学[1] 丁大成[1] 秦军[2] 

机构地区：[1]武汉大学人民医院神经外科,湖北武汉430060 [2]湖北医药学院附属太和医院神经外科二病区,湖北十堰442000

出　　处：《国际神经病学神经外科学杂志》2014年第4期332-337,共6页Journal of International Neurology and Neurosurgery

摘　　要：目的系统评价尼莫地平联合依达拉奉治疗高血压脑出血的临床疗效和安全性。方法严格按照纳入、排除标准,检索PubMed、Cochrane Database of Systematic Reviews、EMbase、CNKI、VIP、Wanfang Data及CBM中关于尼莫地平联合依达拉奉治疗高血压脑出血的随机对照试验(RCT),采用RevMan 5.1软件进行Meta分析。结果共纳入8篇文献,包括610例患者。Meta分析结果显示:尼莫地平联合依达拉奉治疗组在治疗高血压脑出血总有效率明显高于对照组(OR=3.15,95%CI:2.06~4.83);治疗后两组患者神经功能缺损评分、脑血肿、水肿带体积均显著降低(P<0.05),但治疗组神经功能缺损评分、脑血肿、水肿带体积显著低于对照组(P<0.05),且血肿体积较对照组降低显著(SMD=-5.14,95%CI:-5.83^-4.45)。结论尼莫地平联合依达拉奉治疗高血压脑出血临床疗效显著,能促进患者神经功能恢复,有效减少颅内血肿及周围水肿体积。Objective To systematically evaluate the clinical efficacy and safety of nimodipine combined with edaravone in the treat- ment of hypertensive intracerebral hemorrhage （HICH）. Methods The databases of PubMed, Cochrane Database of System Reviews, EMbase, CNKI, VIP, Wanfang Data, and CBM were searched for randomized controlled trials （RCTs） on the efficacy of nimodipine combined with edaravone in the treatment of HICH, which strictly met the inclusion and exclusion criteria. And a meta-analysis was performed using software RevMan （version 5.1 ）. Results A total of g RCTs involving 610 patients with HICH were evaluated. The meta-analysis showed that the overall response rate of the combination therapy group was significantly higher than that of the control group （ OR = 3.15, 95% CI ： 2.06 - 4.83 ）. After treatment, both groups showed significantly reduced neurologic impairment score and volumes of cephalophyma and brain edema （P 〈 0.05 ）, but the neurologic impairment score and volumes of cephalophyma and brain edema in the therapy group were significantly lower than those in the control group （P 〈 O. 05 ）, and the volume of cephalophyma in the therapy group was significantly reduced compared with that in the control group （ SMD = - 5. 14, 95% CI ： - 5. 83 - （ - 4.45） ）. Conclusions For patients with HICH, nimodipine combined with edaravone has significant clinical efficacy in the treat- ment of hypertensive cerebral hemorrhage, and can improve the functional rehabilitation of the nerves and effectively reduce the volumes of intracranial hematoma and peripheral edema.

关 键 词：尼莫地平 依达拉奉 高血压 脑出血 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]