超声心动图分析胎儿单纯室间隔缺损的转归  

Isolated Ventricular Septal Defects in Fetus: A Follow-up Study with Echocardiography

作　　者：齐恩林[1] 马星[1] 刘文瑞[1] 平泽[1] 吴南[1] 刘书海[1] 

机构地区：[1]衡水市哈励逊国际和平医院超声科,河北衡水053000

出　　处：《中国医学影像学杂志》2014年第8期631-633,共3页Chinese Journal of Medical Imaging

基　　金：衡水市科学技术研究与发展指导计划项目(13008Z)

摘　　要：目的应用超声心动图研究单纯室间隔缺损（VSD）在宫内及出生后2年内的自然转归情况及影响因素.资料与方法选择诊断为单纯VSD的65名孕妇为随访对象,记录单纯VSD的发生部位、大小和愈合率.结果65例胎儿中,15例（23.08％）宫内自然愈合,8例（12.31％）于出生后12个月内愈合,17例（26.15％）于出生后13～24个月愈合,25例（38.46％）未愈合.24个月内肌部缺损、膜部缺损及干下型缺损的自然愈合率分别为81.25％（26/32）、43.33％（13/30）、33.33％（1/3）.肌部缺损的愈合率高于膜部缺损（P＜0.05）.VSD＜3.0mm的愈合率明显高于VSD＞3.0mm者（P＜0.01）.结论小的肌部及膜部VSD有较高的宫内及出生后婴儿期自然愈合率,出生后24个月内的自然愈合率也较高.Purpose To evaluate the development and influential factors of isolated small ventricular septal defect （VSD） during gestation and after 2 years of postpartum with echocardiography. Materials and Mothods Sixty-five fetus with isolated VSD were enrolled in the follow-up study, and the location, size and closure rate of the VSD were recorded. Results In all cases, 23.08% （15/65） closed in uterus, 12.31% （8/65） closed during the 12 months after birth, 26.15% （17/65） closed from 13 to 24 months after birth, and 38.46% （25/65） remained unclosed. Spontaneous closure rates were 81.25% （26/32）, 43.33% （13/30） and 33.33% （1/3） in muscular, perimembranous and subarterial VSD, respectively. The closure rate of muscular VSD was higher than that of perimembranous VSD （P〈0.05）. The closure rate of VSD smaller than 3.0 mm was significant higher than that of VSD bigger than 3.0 mm （P〈0.01）. Conclusion Small muscular and perimembranous VSD shows a high spontaneous intrauterine and postnatal closure rate, and the spontaneous closure rate of VSD is also high within 24 months after birth.

关 键 词：室间隔缺损 胎儿疾病 先天畸形 超声检查 产前 超声心动描记术 治疗结果 

分 类 号：R714.5[医药卫生—妇产科学] R540.45[医药卫生—临床医学]