152例结直肠肿瘤患者幽门螺杆菌感染情况分析  

Analysis of the condition of Helicobacter pylori infection in one hundred and fifty-two patients with colorectal tumor

作　　者：陈镇[1] 荣亮[1] 侯慧[1] 刘慧敏[1] 李可[1] 

机构地区：[1]新疆医科大学第五附属医院消化内科,乌鲁木齐830011

出　　处：《中华消化杂志》2014年第10期666-670,共5页Chinese Journal of Digestion

基　　金：新疆医科大学科研创新基金第五附属医院资助项目（XJC2013212）

摘　　要：目的：探讨结直肠肿瘤与H ．pylori 感染的关系。方法回顾性收集2012年1月至2013年1月的152例结直肠肿瘤患者的病例资料。按结肠镜检查结果，将其分成结直肠腺瘤组84例和结直肠癌组68例。另纳入88名健康对照者。比较结直肠腺瘤组、结直肠癌组和健康对照组H ．pylori感染情况的差异。分析结直肠肿瘤组中H ．pylori感染者在不同年龄、性别、民族中的分布。将结直肠腺瘤组分别按腺瘤的所在部位、最大径、数目、蒂部分型、病理分型分亚组，比较各亚组间H ．pylori 感染情况。统计学分析采用卡方检验。结果结直肠腺瘤组、结直肠癌组和健康对照组H ．pylori 感染阳性率分别为70．2％（59/84）、72．1％（49/68）和53．4％（47/88），前两者均高于后者，差异均有统计学意义（χ2＝5．147、5．637，P 均＜0．05）。152例结直肠肿瘤患者中，H ．pylori感染在不同年龄、性别、民族间比较差异均无统计学意义（P 均＞0．05）。84例结直肠腺瘤患者中，按腺瘤所在部位、最大径、数目、蒂部分型、病理分型分亚组，各亚组间 H ．pylori 感染阳性率差异均无统计学意义（P 均＞0．05）。结论H ．pylori感染可能在结直肠肿瘤的发生、发展过程中有促进作用。Objective To explore the relation between the infection of Helicobacter pylori （H .pylori）and colorectal tumor.Methods From January 2012 to January 2013,the medical data of 152 patients with colorectal tumor were collected.According to the findings of colonoscopy examination, the patients were divided into the colorectal adenoma group （84 cases）and the colorectal carcinoma group （68 cases）.A total of 88 healthy individuals were also enrolled as control.The differences of H .pylori infection were compared among the colorectal adenoma group,the colorectal carcinoma group and the healthy control group.The distribution of H .pylori infection in different age,gender and nation was analyzed in colorectal tumor group.According to the location,maximum diameter,number,type of pedicle and pathological type of adenoma,the colorectal adenoma group was divided into subgroups and the condition of H .pylori infection was compared among the subgroups.Chi-square test was used in the statistical analysis.Results The positive rates of H .pylori infection of colorectal adenoma group, colorectal carcinoma group and healthy control group were 70.2% （59/84）,72.1 % （49/68）and 53.4%（47/88）,respectively,where the former two groups were both higher than that of the healthy control group,and the differences were statistically significant （χ2 =5 .147 and 5 .637,both P 〈0.05）.Regarding the H .pylori infection,there was no difference in age,gender and ethnicity among 152 patients with colorectal tumor （all P 〉 0.05 ）.Among 84 patients with colorectal adenoma,there was no statistical difference in the positive rate of H .pylori infection in different location,maximum diameter,number, type of pedicle and pathological type of adenoma （all P 〉 0.05）.Conclusion H .pylori may have promoting effects on the genesis and development of colorectal tumor.

关 键 词：螺杆菌 幽门 结直肠肿瘤 结直肠腺瘤 

分 类 号：R735.34[医药卫生—肿瘤]