DOF方案一线治疗晚期胃癌的疗效观察  

Clinical Observation of DOF Regimen in Treatment of Advanced Gastric Cancer as First Line Chemotherapy

作　　者：熊安稳[1] 王建松[1] 应明真[1] 王雅杰[1] 

机构地区：[1]第二军医大学附属长海医院肿瘤科,上海200433

出　　处：《医学研究杂志》2014年第9期27-30,共4页Journal of Medical Research

基　　金：国家自然科学基金资助项目(81372854;81102010);上海市科委基础研究重点项目(13NM1401504);上海市重点学科建设项目(B905);第二军医大学附属长海医院1255学科建设特色培育项目

摘　　要：目的 评价DOF方案一线治疗晚期胃癌患者的有效性与安全性。方法 收集笔者所在科室2010年1月～2012年12月收治的51例初治晚期胃癌患者,在一线治疗中选用DOF方案化疗。多西他赛75mg/m2,第1天,奥沙利铂135mg/m2,第1天,氟尿嘧啶2400mg/m^2,用化疗泵持续点滴46h,亚叶酸钙200mg/m^2,第1～3天,每21天重复。化疗2～3个周期后影像学检查评价疗效,每周期评价不良反应。结果 化疗总有效率为41.2％,其中完全缓解组0例,部分缓解组21例（41.2％）,病情稳定组19例（37.2％）,疾病进展组11例（21.6％）。中位无进展生存期为5.2个月,主要不良反应为胃肠道反应及骨髓抑制。结论 DOF方案用于治疗晚期初治胃癌疗效确切,耐受性好。Objective To investigate the efficacy and safety of docetaxel and oxaliplatin plus fluorouracil（DOF） against advanced gastric cancer patients.Methods Fifty-one advanced or metastatic gastric cancer patients were treated by docetaxel 75mg/m^2 （day 1） and oxaliplatin 135mg/m^2 （day 1） plus fluorouracil 2400mg/m^2 （Ⅳ over 46h）,Leucovorin 200mg/m2 （day 1 to 3） every 2-3 weeks from January 2010 to December 2012.Response evaluation was performed every three cycles and toxicity was observed every cycle.Results The response rate was 41.2%.No complete response（CR） was seen,and partial response（PR） was seen in 21 patients（41.2%）.Stable disease （SD） was seen in 19 patients（37.2%）.Progressive desease （PD） was seen in 11 patients（21.6%）.The median progressive free survival was 5.2 months.The most frequent adverse reaction were bone marrow depression and gastrointestinal tract reaction.Conclusion The DOF regimen is an effective,safe and well-tolerated regimen for patients with advanced gastric cancer who have not previously received chemotherapy.

关 键 词：晚期胃癌 一线治疗 奥沙利铂 

分 类 号：R735.2[医药卫生—肿瘤]