miR-148a在胃癌中作用的研究进展  

Advances in research of miR-148a in gastric cancer

作　　者：欧阳喜[1] 夏克江 陈子文[1] 朱培谦[1] 

机构地区：[1]南昌大学第二附属医院胃肠外科,江西省南昌市330006

出　　处：《世界华人消化杂志》2014年第20期2839-2844,共6页World Chinese Journal of Digestology

摘　　要：胃癌是最常见的消化系恶性肿瘤之一,近年来我国胃癌的发病率有上升趋势,手术切除是胃癌治疗的首选方法.但我国早期胃癌的诊断率不高,胃癌根治术后患者的生存质量及5年生存率偏低.微小RNA是一类小分子非编码RNA,已经有许多研究报道证实其参与肿瘤的发生、发展过程.其中miR-148a分子在胃癌中的作用日益受到重视,这为胃癌的诊断、治疗提供了新的可能.本文就近年来miR-148a在胃癌的作用方面的研究进展作一综述.Gastric cancer is one of the most frequent malignancies of the digestive system, and its incidence is on the rise in recent years. Surgical resection is the preferred treatment for gastric cancer. However, the rate of diagnosis of early gastric cancer is not high, and the quality of survival and 5-year survival rate of gastric cancer patients are low. MicroRNAs are a class of small non-coding RNAs that have been demonstrated to participate in tumor occurrence and development. The role of miR-148a in gastric cancer has received increasing attention in recent years, which offers a new possibility for the diagnosis and treatment of gastric cancer. This review summarizes the advances in understanding the role of miR-148a in gastric cancer.

关 键 词：miR-148a 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]