生长抑素治疗消化性溃疡大出血的临床疗效  

Efficacy of somatostatin in treatment of massive peptic ulcer bleeding

作　　者：杨英碧 李玲 陈金春 熊韦韦 陈祥 

机构地区：[1]贵州省水城矿业总医院,贵州省六盘水市553000

出　　处：《世界华人消化杂志》2014年第20期2977-2980,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨生长抑素(坎立宁)治疗消化性溃疡大出血(peptic ulcer bleeding,PUB)的临床疗效.方法:按照数字随机分组法我院收治的86例PUB患者均分为观察组和对照组,两组患者入院后均禁食,给予急性上消化道出血常规护理和治疗干预,观察组患者在此基础上加用生长抑素治疗,比较两组患者治疗后6、12、24和48 h止血情况、72 h再出血率及不良反应发生情况.结果:观察组患者治疗后6、12、24和48 h止血率均显著高于对照组(51.16%vs 27.91%,76.74%vs 53.49%,86.05%vs 65.12%,97.67%vs 79.07%),差异具有统计学意义(P<0.05);两组患者72 h再出血率和不良反应发生率比较(2.33%vs 6.98%,4.65%vs 11.63%),差异无统计学意义(P>0.05).结论:在急性上消化道出血常规护理和治疗干预基础上加用生长抑素能够有效缩短止血时间,提高止血率,在一定程度上也减少了患者72 h内复发出血的情况发生,临床应用价值较高.AIM： To assess the clinical effects of sandostatin in treating massive peptic ulcer bleeding（PUB）. METHODS： Eighty-six patients with PUB were randomly divided into either an experiment group or a control group. Both the control and treatment groups underwent fasting, routine nursing and therapeutic intervention, and the experiment group was additionally given somatostatin. The bleeding status at 6, 12, 24 and 48 h, the rebleeding rate after 72 h and adverse reactions were compared between the two groups.RESULTS： The bleeding rates at 6, 12, 24 and 24 h were significantly higher in the experiment group than in the control group（51.16% vs 27.91%, 76.74% vs 53.49%, 86.05% vs 65.12%, 97.67% vs 79.07%; P〈0.05）. There was no significant difference in the rebleeding rate or the rate of adverse reactions between the two groups （2.33% vs 6.98%, 4.65% vs 11.63%, P〉0.05）.CONCLUSION： Somatostatin can shorten the time of hemostasis and improve the bleeding rate in patients with massive peptic ulcer bleeding.

关 键 词：生长抑素 消化性溃疡大出血 止血率 临床疗效 

分 类 号：R573.1[医药卫生—消化系统]