轻微型肝性脑病诊断的研究进展  

Progress in diagnosis of minimal hepatic encephalopathy

作　　者：蒲艳[1] 杨晋辉[1] 杨婧[1] 胥莹[1] 唐映梅[1] 

机构地区：[1]昆明医科大学第二附属医院肝胆胰内科,云南省昆明市650101

出　　处：《世界华人消化杂志》2014年第25期3759-3765,共7页World Chinese Journal of Digestology

摘　　要：轻微型肝性脑病(minimal hepatic encephalopathy,MHE)是指无明显临床症状和神经系统检查异常,但用精细的智力测验或神经电生理检查可发现异常.因其损害患者的工作、驾驶、记忆、认知等功能,且容易发展为显性肝性脑病,与非MHE患者相比病死率较高,因此需要积极筛查并干预MHE患者,提高肝硬化患者的生活质量,减少交通事故发生并减轻社会医疗负担.目前MHE的诊断方法主要包括精神量表(纸-笔测验、计算机测验及二者联合)、神经电生理检查、影像学检查.目前临床上对于MHE的诊断仍是一个挑战,需要进一步完善诊断标准和增强诊断的准确性.Minimal hepatic encephalopathy（MHE） is defined as HE without symptoms on clinical/neurological examination, but with deficits in some cognitive areas that can only be measured by neuropsychometric testing. MHE is associated with reduced quality of working, driving, memory, and cognitive function, and is a risk factor for the development of overt HE. Compared with non-MHE patients, MHE patients have a high mortality rate, so positive screening and intervention in patients with MHE are needed to improve the quality of life in patients with cirrhosis and reduce traffic accidents and the social burden of medical care. The current approach to the diagnosis of MHE includes mental scales（paper pencil test, computer test, or the combination of the two）, electrophysiological examination, and imaging examination. Diagnosis of MHE is still a challenge now, and it is needed to establish a better clinical diagnosis standard to improve the diagnostic level.

关 键 词：轻微型肝性脑病 诊断 

分 类 号：R747.9[医药卫生—神经病学与精神病学]