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出 处:《中华病理学杂志》2014年第10期677-679,共3页Chinese Journal of Pathology
摘 要:目的 探讨2005年国际泌尿病理协会(ISUP)前列腺癌Gleason评分(GS)系统对前列腺癌分级的影响.方法 分别使用1977年GS修订版(简称修订版)和ISUP版GS系统,对112例穿刺活检、18例经尿道前列腺切除以及55例根治性前列腺切除标本进行评分,并观察各分级所占的比例,比较两个版本GS的差异.结果 在GS 3 +3、GS 3 +4以及GS 4 +3评分中,修订版所占比例分别为47.0%(87/185)、11.4% (21/185)以及17.3%(32/185),而ISUP版分别为25.9% (48/185)、21.6% (40/185)以及27.6%(51/185).在主要分级中,3级和4级所占比例:修订版分别为62.7%(116/185)和31.4%(58/185),ISUP版则为50.8% (94/185)和41.6% (77/185).关于次要分级,3级和4级所占比例:修订版分别占65.9%(122/185)和21.1% (39/185),ISUP版分别占54.6%(101/185)和31.4%(58/185).结论 ISUP版与修订版GS存在一定差异.与修订版相比,ISUP版GS3 +3比例呈现下降趋势,而GS 3 +4和GS4 +3比例呈现上升趋势.Objective To explore the impact of the 2005 International Association of Urological Pathology (ISUP) Gleason score (GS) system on prostatic carcinoma grading.Methods Using the 1977revision and ISUP version of GS system,112 needle biopsies,18 transurethral resections of the prostate and 55 radical prostatectomies were scored.The proportion of grading discrepancy was observed and compared between the two versions of GS.Results Gleason scores of 3 + 3,3 + 4 and 4 + 3 accounted for 47.0%(87/185),11.4% (21/185) and 17.3% (32/185) in the modified system,and accounted for 25.9%(48/185),21.6% (40/185) and 27.6 % (51/185) in ISUP system,respectively.The percentages of primary grade by modified vs.ISUP system were 62.7% (116/185) vs.50.8% (94/185) for grade 3,and 31.4% (58/185) vs.41.6% (77/185) for grade 4.The percentages of secondary grade by modified vs.ISUP system were 65.9% (122/185) vs.54.6% (101/185) for grade 3,and 21.1% (39/185) vs.31.4% (58/185) for grade 4.Conclusions ISUP system is different from the modified system.Compared with the modified system,the proportion scored by ISUP system tends to decline for GS 3 + 3 but increase for GS 3 +4 and 4 +3.
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