含取代2-苯基吡啶基团的甲氧基氨基甲酸酯类化合物的合成及杀螨活性  

Synthesis and acaricidal activity of methoxylcarbamates containing substituted 2-phenylpyridine moieties

作　　者：毛达杰[1,2] 李以名[3] 刘建华[1] 胡崇波[1] 杜晓华[1] 徐振元[1] 

机构地区：[1]浙江工业大学催化加氢研究中心,浙江省绿色农药清洁生产技术研究重点实验室,杭州310014 [2]中化宁波(集团)有限公司,浙江宁波315000 [3]嘉兴学院生物与化学工程学院,浙江嘉兴314001

出　　处：《农药学学报》2014年第5期600-604,共5页Chinese Journal of Pesticide Science

摘　　要：以取代2-溴吡啶和羟基苯硼酸为原料,经Suzuki偶联和亲核取代两步反应合成了9个未见报道的含取代2-苯基吡啶基团的甲氧基氨基甲酸酯类化合物,其结构均经红外光谱、核磁共振氢谱及质谱(ESI-MS)表征。初步生物活性测定结果表明:在500 mg/L下,部分化合物对朱砂叶螨Tetranychus cinnabarinus的致死率达100%,具有作为杀螨剂先导结构的潜力。Nine novel methoxylcarbamates containing substituted 2-phenylpyridine moieties were synthesized from hydroxyphenylboronic acid and substituted 2-bromopyridine via Suzuki cross-coupling reaction and nucleophilic substitution sequence. Their structures were characterized by IR,1 H NMR and ESI-MS. The preliminary bioassay showed that some compounds exhibited excellent lethality against Tetranychus cinnabarinus at 500 mg/L. The results indicated that above methoxylcarbamates can serve as potential acaricidal lead compounds.

关 键 词：取代2-苯基吡啶 甲氧基氨基甲酸酯 合成 杀螨活性 

分 类 号：S482.3[农业科学—农药学]