度洛西汀治疗慢性酒依赖伴抑郁的临床疗效研究  

The efficacy and safety of Duloxetine in the treatment of Alcohol Abuse patients with Depression

作　　者：白凤凤[1] 李涛[1] 刘娟[1] 孙伟[1] 高营[1] 

机构地区：[1]天津市安定医院,天津市300222

出　　处：《中国药物滥用防治杂志》2014年第5期259-261,266,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨度洛西汀在慢性酒依赖伴抑郁患者中的临床疗效及安全性。方法:将符合条件的66例慢性酒依赖伴抑郁患者随机分成两组,分别给予度洛西汀联合常规戒酒治疗(研究组)和常规戒酒治疗(对照组),进行8周的系统治疗,使用HAMD(汉密尔顿抑郁量表),HAMA(汉密尔顿焦虑量表),CGI(临床疗效总体评估量表),饮酒渴求度评估其疗效;以TESS(副反应量表)和有关的实验室检查评定药物副反应。结果:治疗以后,研究组与对照组相比较,研究组第1、2、4、8周HAMD-17、HAMA、CGI评分明显下降(P<0.05或P<0.01);与对照组相比,研究组第1、2、4、8周的饮酒渴求度明显降低(P<0.05或P<0.01)。结论:度洛西汀治疗酒依赖伴抑郁安全有效,并能明显降低酒依赖患者的心理渴求。Objective：To explore the efficacy and safety of Duloxetine in treating alcohol abuse patients with depression. Methods：66 alcohol abuse patients with depression were randomly divided into Duloxetine group（n = 33）and Controll group（n = 33）. Duloxe-tine group was treated by Duloxetine combined with regular treatment of alcohol abuse. Controll group was treated by regular treatment of alcohol abuse only. They were treated for 8 weeks. The efficacy and safety were evaluated at the baseline and at the end of week 1, 2,4,8 respectively. Results：At the end of the study,The Duloxetine group was significantly improved. The scales of HAMD/ HAMA decreased significantly at the end of week 1,2,4,8 in Duloxetine group（P〈0. 05）. The Duloxetine group was significantly lowered down the patients alcohol craving. Conclusion：Duloxetine is a safe and effective drug in the treatment of alcohol abuse patients with depression.

关 键 词：度洛西汀 酒依赖 抑郁 

分 类 号：R749.6[医药卫生—神经病学与精神病学]