阿司匹林、盐酸氟桂利嗪联合葛根素葡萄糖注射液治疗椎基底动脉供血不足的临床观察  

Clinical Observation of Aspirin and Flunarizine Hydrochloride Combined with Puerarin Glucose Injection in the Treatment of Vertebrobasilar Insufficiency

作　　者：杜鹤峣 赵小兰[1] 

机构地区：[1]第三军医大学西南医院,重庆400038

出　　处：《中国药房》2014年第40期3778-3780,共3页China Pharmacy

摘　　要：目的:观察阿司匹林、盐酸氟桂利嗪联合葛根素葡萄糖注射液治疗椎基底动脉供血不足(VBI)的临床疗效和安全性。方法:218例VBI患者按随机数字表法均分为对照组和观察组。对照组患者给予阿司匹林肠溶片0.1 g,口服,每日1次+盐酸氟桂利嗪胶囊10 mg,口服,每晚1次;观察组患者在对照组治疗的基础上给予葛根素葡萄糖注射液250 ml静脉滴注,每日1次。两组患者疗程均为14 d。观察两组患者临床疗效,治疗前后左椎动脉(LVA)血液平均血流速度(Vm)、右椎动脉(RVA)Vm、基底动脉(BA)Vm及不良反应发生情况。结果:两组共208例患者完成疗程(对照组102例,观察组106例)。观察组患者总有效率显著高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后两组患者LVAVm、RVAVm、BAVm均显著高于同组治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿司匹林、盐酸氟桂利嗪联合葛根素葡萄糖注射液治疗VBI较阿司匹林联合盐酸氟桂利嗪疗效更显著,安全性较好。OBJECTIVE： To observe the clinical efficacy and safety of aspirin and flunarizine hydrochloride combined with Pu- erarin glucose injection in the treatment of vertebrobasilar insufficiency. METHODS： 218 VBI patients were randomly divided into control group and observation group. Control group was given Aspirin enteric-coated tablet 0.1 g orally, once a day＋Flunarizine hy- drochloride capsules 10 mg once every night; observation group was given Puerarin glucose injection 250 ml once a day. Treatment course of 2 groups lasted for 14 d. Clinical efficacies of 2 groups were observed, and LVAVm, RVAVm, BAVm and ADR were ob- served before and after treatment. RESULTS： A total of 208 patients completed treatment in 2 groups （102 cases in control group, 106 cases in observation group）. The total effective rate of observation group was significantly higher than that of control group; there was statistical significance （P〈0.05）. LVAVm, RVAVm and BAVm of 2 groups after treatment were significantly higher than before; the observation group was higher than the control group; there was statistical significance （P〈0.05）. There was no statisti- cal significance in the incidence of ADR between 2 groups （P〉0.05）. CONCLUSIONS： Aspirin and flunarizine hydrochloride com- bined with Puerarin glucose injection is better than aspirin combined with flunarizine hydrochloride for VBI in therapeutic efficacy and safety.

关 键 词：阿司匹林 盐酸氟桂利嗪 葛根素葡萄糖注射液 椎基底动脉供血不足 

分 类 号：R743.9[医药卫生—神经病学与精神病学]