β-半乳糖凝集素3和生物钟基因PER2在非小细胞肺癌中的表达及其临床意义  

The expression and clinical significance of β- Galactose lectin 3and clock genes PER2 in non-small cell lung cancer

作　　者：张艳红[1] 赵桂凤[2] 尹奎夫[1] 刘美华[1] 魏秀平[1] 

机构地区：[1]潍坊市妇幼保健院内科,山东潍坊261000 [2]潍坊市人民医院,山东潍坊261000

出　　处：《中国卫生检验杂志》2014年第18期2692-2694,共3页Chinese Journal of Health Laboratory Technology

基　　金：2012年度山东省潍坊市卫生局科研项目计划040号

摘　　要：目的研究β-半乳糖凝集素3(Gal-3)和生物钟基因PER2在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及其临床意义。方法采用免疫组化法检测Ga1-3蛋白和生物钟基因PER2在90例NSCLC组织和20例正常肺组织中的表达。结果在NSCLC组织中和正常组织中Ga1-3蛋白的阳性表达率分别为56.7%、25%(P<0.05),PER2的阳性表达率分别为58.9%、85%(P<0.05)。Gal-3的表达与NSCLC分化程度、淋巴结转移情况和TNM分期有关(P<0.05)。结论与正常组织相比较,在非小细胞肺癌中,Gal-3呈高表达,PER2呈低表达。推测Gal-3、PER2在NSCLC的发生、发展中可能起到重要作用。Objective To discuss the expression and clinical significance of β- Galactose lectin 3 and Clock genes PER2 in non- small cell lung cancer. Methods Study the expression of β- Galactose lectin 3 and Clock genes PER2 in 90 cases of non- small cell lung cancer tissue and 20 cases of normal lung tissue by immunohistochemical method. Results The expression rate of β- Galactose lectin 3 in non- small cell lung cancer tissue was 56. 7%,while in the normal lung tissue was 25%（ P〈0. 05）. The expression rate of Clock genes PER2 in non- small cell lung cancer tissue was 58. 9%,while in the normal lung tissue was 85%（ P〈0. 05）. The expression of β- Galactose lectin 3 in non- small cell lung cancer was related with the differentiation degree,Lymph node metastasis and TNM staging（ P〈0. 05）. Conclusion Compared with the normal tissue,the β-Galactose lectin 3 was higher expression and Clock genes PER2 was lower expression in the non- small cell lung cancer. We can infer the β- Galactose lectin 3 and Clock genes PER2 played an important role in the occuring and developing of non-small cell lung cancer.

关 键 词：非小细胞肺癌 β-半乳糖凝集素3 生物钟基因PER2 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]