伴有与不伴有代谢综合征的首发精神分裂症患者认知功能的研究  

Studies on cognitive function in patients of first-episode schizophrenia with and without metabolic syndrome

作　　者：朱春燕[1] 孙继军[2] 申变红[1] 江长旺[1] 陶云海[1] 施剑飞[1] 

机构地区：[1]杭州市第七人民医院一病区,310013 [2]杭州市第七人民医院四病区,310013

出　　处：《中国医师进修杂志》2014年第28期1-4,共4页Chinese Journal of Postgraduates of Medicine

基　　金：浙江省卫生厅科研项目计划（2011KYA134）

摘　　要：目的 探讨伴有与不伴有代谢综合征首发精神分裂症患者认知功能的差别.方法 对57例伴有代谢综合征的首发精神分裂症患者（研究组）和57例不伴有代谢综合征的首发精神分裂症患者（对照组）进行事件相关电位检测和韦氏记忆量表（WMS）测定,并应用阳性和阴性症状量表（PANSS）对两组进行精神病理学评定.结果 记忆商数研究组（78.51±12.54）分,对照组（92.01±17.49）分,两组差异有统计学意义（t=-2.130、P=0.047）,研究组短时记忆、瞬时记忆受损均高于对照组（t=2.151 ～ 3.054、P=0.007～0.046）;P300潜伏期研究组（325.10±22.46）ms,对照组（284.60±22.46）ms,两组差异有统计学意义（t=3.454、P=0.003）,P300波幅研究组（6.56±1.61）μV,对照组（9.78±1.73） μV,差异有统计学意义（t=-4.307、P=0.000）.结论 伴有代谢综合征的首发精神分裂症患者比不伴有代谢综合征的首发精神分裂症患者存在更严重的认知功能损害.Objective To discuss the difference of cognitive function in patients of first-episode schizophrenia with and without metabolic syndrome.Methods Event related potential detection and Wechsler Memory Scale （WMS） was determined in 57 patients of first-episode schizophrenia with metabolic syndrome （research group） and 57 patients of first-episode schizophrenia without metabolic syndrome （control group）,and the psychiatric symptom in two groups was assessed by the application of the positive and negative symptoms scale （PANSS）.Results The memory quotient score was （78.51 ± 12.54） scores in research group,and （92.01 ± 17.49） scores in control group,and there was significant difference between two groups （t =-2.130,P=0.047）.The short-term memory,instantaneous memory impairment in research group were lower than those in control group（t =2.151-3.054,P=0.007-0.046）.The latency of P300 was （325.10 ±22.46） ms in research group and （284.60 ±22.46） ms in control group,and there was significant difference （t =3.454,P =0.003）.The amplitude was （6.56 ± 1.61） μ V in research group and （9.78 ±1.73） μV in control group,and there was significant difference （t =-4.307,P =0.000）.Conclusion The patients of first-episode schizophrenia with metabolism syndrome has more severe cognitive impairment than those without metabolism syndrome.

关 键 词：代谢综合征 精神分裂症 认知 事件相关电位 韦氏记忆量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]