miR-126/miR-126*在肝细胞癌中的表达及其与临床预后的相关性  

Expression of miR-126/miR-126* in hepatocelluar carcinoma and its correlation with clinical outcomes

作　　者：何华[1] 黄毓[1] 杨定华[1] 梁博[1] 林梁[1] 李佳璐[1] 廖晖[1] 郭柏棠[1] 

机构地区：[1]南方医科大学南方医院肝胆外科,广东广州510515

出　　处：《南方医科大学学报》2014年第10期1493-1497,共5页Journal of Southern Medical University

基　　金：广东省自然科学基金(10151051501000120)

摘　　要：目的研究miR-126/miR-126*在肝细胞癌中的表达,探讨其表达与相关临床病理参数的关系。方法用RT-QPCR方法检测74例肝细胞癌手术切除的癌组织与相应的非癌组织中miR-126/miR-126*的表达,分析其表达与相关临床病理参数的关系。结果 miR-126/miR-126*在癌组织中表达水平显著低于相对应的非癌组织;miR-126/miR-126*在肝癌中的表达呈正相关关系;复发组癌组织中miR-126/miR-126*的表达显著低于未复发组癌组织;miR-126/miR-126*高表达组无瘤生存时间显著优于低表达组。结论 miR-126/miR-126*的的低表达可能是影响肝细胞癌转移并导致患者不良预后的一个重要因素。Objective To investigate the expression of miR- 126/miR- 126＊ in hepatocellular carcinoma（HCC） tissues and its clinical significance. Methods The expressions of miR-126/miR-126＊ in the tumor tissues and non-cancer tissues from 74 HCC cases were detected using real- time quantitative PCR. The correlation between miR- 126/miR- 126＊ expression and the clinicopathological features of the patients was analyzed. Results Compared with the non-cancer tissues, HCC tissues showed significantly lowered expression levels of miR-126/miR-126＊. A positive correlation was found between the expressions of miR-126 and miR- 126＊ in the tumor tissues. Lower expressions of miR- 126/miR- 126＊ were significantly correlated with tumor recurrence and poor survival of the HCC patients. Conclusion The down- regulation of miR- 126/miR- 126＊ may play an important role in HCC metastasis and contributes to poor survival of HCC patients.

关 键 词：MIR-126 miR-126＊ 肝细胞癌 荧光定量PCR 

分 类 号：R735.7[医药卫生—肿瘤]