高渗盐水浸泡剥离法联合丝裂霉素C治疗翼状胬肉疗效观察  

Hypertonic saline soaked peeling combined with mitomycin C for the treatment of pterygium

作　　者：李双勇[1] 曾祥泰[1] 张蕾[3] 杨一涛[2] 罗瑛[3] 黄文[1] 曾敏波 钟裔林 

机构地区：[1]赣南医学院第二附属医院,江西341600 [2]菏泽市立医院,山东274000 [3]赣南医学院第一附属医院,江西341000

出　　处：《中国实用眼科杂志》2014年第9期1113-1115,共3页Chinese Journal of Practical Ophthalmology

基　　金：赣州市指导性科技计划（2011-163）

摘　　要：目的探讨高渗盐水浸泡剥离法联合丝裂霉素C（MMC）手术治疗翼状胬肉的临床疗效和安全性。方法对2010年5月至2012年9月在赣南医学院第二附属医院眼科就诊的104例（124只眼）原发性翼状胬肉患者，按手术方法分为A、B两组：A组53例（64只眼）采用5％高渗盐水浸泡剥离法联合MMC的手术方式进行治疗，B组51例（60只眼）采用单纯性翼状胬肉切除术。术后随访12个月，比较两组患者术后复发率及创面角膜上皮修复时间。结果A组64只眼中有5只眼复发，复发率为7.81％（5／64）；B组60只眼中有16只眼复发，复发率为26.67％（16／60），两者比较差异有统计学意义（x2=7.8255，P=0.005）。角膜创面上皮平均修复时间A组为（4.64±0.98）d，B组为（5.10±1.05）d，两者比较差异有统计学意义（t=2.514，P=0.013）。两组均未出现严重并发症。结论高渗盐水浸泡剥离法联合MMC治疗原发性翼状胬肉，术后角膜创面修复快，胬肉复发率低，方法简便，安全有效，值得推广及应用。Objective To evaluate the effectiveness and safety of hypertonic saline （5% sodium chloride） soaked peeling combined with mitomycin C （MMC） in the treatment of pterygium. Methods According to the operation method, 104 cases （124 eyes） with primary pterygiums were divided into two groups： hypertonic saline soaked peeling combined with MMC group （group A, 53 cases, 64 eyes） and pure excision group （group B, 51 cases, 60 eyes）. All cases were followed up for 12 months, and then compared the recurrence rate and epithelia recovering time of corneal wound. Results The recurrence rate was 7.81% in group A, （5 of 64 eyes were recurred）; the recurrence rate was 26,67% in group B, （16 of 60 eyes were recurred）, the difference between the two groups was statistically significant （x2=7.8255, P =0.005）. The mean time of epithelial healing was （4.64±0.98） days in group A, while （5.10±1.05） days in group B, the difference of epithelial healing time between the two groups was statistically significant （t =2.514, P =0.013）. No severe complications were found in two groups. Conclusions Hypertonic saline soaked peeling combined with MMC in the treatment of primary pterygium can decrease the recurrence rate, improve epithelia recovering time of corneal wound. It is simple, safe and effective, is worthy of promotion and application.

关 键 词：翼状胬肉 高渗盐水 丝裂霉素C 

分 类 号：R777.330.5[医药卫生—眼科]