自身免疫性葡萄膜炎与Th1、Th17相关细胞因子的研究进展  

Current research in the relationship between Thl/Th17-related cytokines and autoimmune uveitis

作　　者：陈暐[1] 陈玲[1] 

机构地区：[1]复旦大学附属眼耳鼻喉科医院眼科,上海200031

出　　处：《中华实验眼科杂志》2014年第10期943-949,共7页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目（81000381）;国家重点基础研究计划项目（2013CB967503）;教育部留学回国人员科研启动基金项目（42批）;上海浦江人才基金A类资助项目（10PJ1401900）

摘　　要：人类自身免疫性葡萄膜炎是一组常见的眼部炎症性疾病，不明因素导致的自身免疫紊乱可对眼部组织产生不可逆性损害，因此长期以来，对人类自身免疫性葡萄膜炎的致病原因、发病机制的研究从未停止。以往的研究认为，1型辅助性T细胞群（Th1）是诱发人类自身免疫性葡萄膜炎的关键因素，但近年来发现，Th17是诱导自身免疫性葡萄膜炎病变的主要因素。由于每种Th细胞群都有其特定的细胞因子及转录因子，这些细胞因子通过调节Th1、Th2、Th17的表达及平衡决定着自身免疫性葡萄膜炎的发生和发展。研究Th1及Th17相关细胞因子在病变中的作用是探讨自身免疫性葡萄膜炎发生和发展的重要基础之一。就近年来Th1及Th17主要的相关细胞因子在葡萄膜炎的致病性、调节及治疗作用方面的研究进展进行综述。Human autoimmune uveitis encompasses a diverse group of common ocular inflammatory diseases. Unknown factors trigger the breakdown of self-tolerance and subsequently lead to the irreversible vision impairment. So the explore and research has never ceased for a long time. Previous study indicated that T helper lymphocyte 1 （Th1） plays a key role in the pathogenesis and development of human autoimmune uveitis. But recently accumulating evidences from both animal and clinical studies suggest that Th17 participates in the pathological mechanism of human autoimmune uveitis. Studies showed that Thl and Th17 determine the pathological process by the regulation signal of specific cytokines and transcription factors. More and more evidences revealed that Thl and Th17 are the predominant influences in induction of uveitis. Unveiling the roles of Thl/Th17-related cytokines will help to elucidate the mechanism and progression of uveitis. Recent findings of Thl/ThlT-related cytokines regarding pathogenesis and regulation attributed in uveitis were summarized and the novel viewpoint of treatments was discussed.

关 键 词：葡萄膜炎/免疫 自身免疫 CD4^+辅助性T细胞 细胞因子 

分 类 号：R773[医药卫生—眼科]