p16、p53、CerbB2和ki-67在胃癌及癌前病变中的表达及意义  

Expression and significance of p16, p53 and CerbB2 and Ki-67 of in the gastric cancer and precancerous lesions

作　　者：贾振军[1] 郭雪洁[1] 苗新东[1] 臧学良 李化新[2] 

机构地区：[1]山东铝业公司医院病理科,山东淄博255069 [2]山东铝业公司医院普外科,山东淄博255069

出　　处：《中国现代普通外科进展》2014年第8期611-615,共5页Chinese Journal of Current Advances in General Surgery

基　　金：山东铝业公司科技计划项目(SLYF 2014-3)

摘　　要：目的:探讨p16、p53、Cerb B2和ki-67在慢性胃炎、异型增生、胃癌及癌旁组织中的表达及临床意义。方法:采用免疫组织化学SP法对慢性胃炎组织、异型增生组织、胃癌组织及癌旁组织分别行p16、p53、Cerb B2和ki-67检测。结果:p16在慢性胃炎、低级别异型增生、高级别异型增生、胃癌及癌旁组织中的表达阳性率分别为25.49%、30.39%、33.93%、33.55%和32.69%。p53在慢性胃炎、低级别异型增生、高级别异型增生、胃癌及癌旁组织中的表达阳性率分别为0、0、21.43%、50.00%和13.46%。Cerb B-2在慢性胃炎、低级别异型增生、高级别异型增生、胃癌及癌旁组织中的表达阳性率分别为0、0、14.29%、25.66%和9.62%。ki-67在慢性胃炎、低级别异型增生、高级别异型增生、胃癌及癌旁组织中的表达阳性率分别为15.69%、43.14%、57.14%、75.66%和42.31%。结论:p16、p53、Cerb B-2和ki-67在癌前病变中异常表达,可作为判断胃癌及癌前病变的重要参考指标。Objective：Analysis of expression of p16,p53,CerbB-2 and ki-67 in chronic gastritis,gastric epithelial dysplasia,gastric cancer and tissues adjacent to cancer.To investigate the relationship between chronic gastritis,gastric epithelial dysplasia and gastric cancer.Method：On 102 cases of chronic gastritis,158 cases of gastric epithelial dysplasia,152 cases of gastric cancer,56 cases of tissues adjacent to cancer with SP immunohistochemical method,respectively p16,p53,CerbB-2 and ki-67 detection.Results：p16 in the chronic gastritis,low grade gastric epithelial dysplasia,high grade gastric epithelial dysplasia,gastric carcinoma and tissues adjacent to cancer in positive expression rates were 25.49％,30.39％,33.93％,33.55％,32.69％.p53 in the chronic gastritis,low grade gastric epithelial dysplasia,high grade gastric epithelial dysplasia,gastric carcinoma and tissues adjacent to cancer in positive expression rates were 0,0,21.43％,50％,13.46％.CerbB-2 in the chronic gastritis,low grade gastric epithelial dysplasia,high grade gastric epithelial dysplasia,gastric carcinoma and tissues adjacent to cancer in positive expression rates were 0,0,14.29％,25.66％,9.62％.ki-67 in the chronic gastritis,low grade gastric epithelial dysplasia,high grade gastric epithelial dysplasia,gastric carcinoma and tissues adjacent to cancer in positive expression rates were 15.69％,43.14％,57.14％,75.66％,42.31％.Conclusion：Relationship of high grade gastric epithelial dysplasia tissues,tissues adjacent to cancer and gastric cancer are closely.

关 键 词：胃肿瘤 P16 p53 CERBB-2 KI67 

分 类 号：R735.2[医药卫生—肿瘤]