表面修饰疏水性丙烯酸酯人工晶状体表面超微结构的观察  

Study on surface microstructure of surface modified hydrophobic acrylic intraocular lens

作　　者：王桂琴[1] 曹利群[1] 李娜[1] 彭秀军[1] 唐慧琴[2] 董亚利[2] 顾汉卿[2] 

机构地区：[1]海军总医院眼科,北京市100048 [2]天津医科大学,天津市300211

出　　处：《眼科新进展》2014年第10期904-906,共3页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81070716)~~

摘　　要：目的改变疏水性丙烯酸酯人工晶状体的前表面性能,并进行改性后观察人工晶状体表面超微结构。方法采用表面修饰技术对疏水性丙烯酸酯人工晶状体前表面进行乙烯基吡咯烷酮单体以及氧化钛单面修饰并观察其表面形貌;修饰人工晶状体植入兔眼,于术后90 d摘出修饰人工晶状体行扫描电镜观察。结果扫描电镜结果表明,与未修饰人工晶状体相比,改性处理后的人工晶状体表面更均匀光滑。未修饰人工晶状体植入兔眼术后90 d,人工晶状体表面黏附有细胞以及蛋白膜附着物,黏附细胞多为大小及形态多样的巨噬细胞,主要集中于人工晶状体周边。修饰人工晶状体表面黏附细胞少于未修饰人工晶状体,乙烯基吡咯烷酮单体修饰人工晶状体表面黏附细胞更少。结论表面修饰的疏水性丙烯酸酯人工晶状体提高了人工晶状体的葡萄膜生物相容性。Objective To modify the anterior surface of hydrophobic acrylic intraocular lens（IOL）,then observe the microstructure changes on the surface of those IOL. Methods Monomer vinyl pyrrolidone was grafted onto the hydrophobic acrylic IOL,and the TiO2 surface modification were produced. After their micro-roughness characteristics were observed under scanning electron microscope,the modified IOL were implanted into eyes of rabbits. The IOL were extracted at 90 days after surgery and observed by scanning electron microscopy. Results Under scanning electron microscope,the modified IOL became more uniform and smooth compared with non-modified IOL. Cells and fibrinous proteinic membrane adhered to the surface of extracted IOL at 90 days after surgery. Most of the adherence cells were detected as macrophages of different size and shape,which concentrated on the periphery of IOL. The adherence cells were found less on the surface of modified lenses,which were few on the surface of monomer vinyl pyrrolidone modified lenses. Conclusion The surface modified hydrophobic acrylic IOL can improve its uveal biocompatibility.

关 键 词：人工晶状体 表面修饰 葡萄膜生物相容性 

分 类 号：R776.1[医药卫生—眼科]