两种不同表面麻醉剂对泪液分泌试验结果的影响  

Effects of two different topical anesthetics on Schirmer I test

作　　者：牛晓光[1] 徐曼[1] 夏桂花[1] 路月 

机构地区：[1]汉口爱尔眼科医院,湖北省武汉市430060

出　　处：《眼科新进展》2014年第10期981-983,共3页Recent Advances in Ophthalmology

摘　　要：目的观察两种不同的表面麻醉剂对基础泪液分泌试验(Schirmer I test,SIT)的影响。方法选取我院准分子门诊就诊患者84例(168眼),其中男51例(102眼),女33例(66眼),同一患者左右眼随机分别以5 g·L-1盐酸丙美卡因滴眼液和4g·L-1盐酸奥布卡因滴眼液1滴单次滴眼,观察滴眼后的眼部刺激症状及结膜充血情况,测量其SIT值,并对结果进行比较分析。结果盐酸丙美卡因组有15眼出现一过性眼部刺激症状,盐酸奥布卡因组有33眼,两组比较差异有统计学意义(P<0.05);盐酸丙美卡因组轻度结膜充血的眼数为54眼,明显多于盐酸奥布卡因组的39眼(P<0.05);盐酸丙美卡因组SIT值为(7.50±5.15)mm,盐酸奥布卡因组为(9.71±5.46)mm,两组间比较差异有统计学意义(P<0.05);盐酸丙美卡因组48眼SIT值小于10 mm,盐酸奥布卡因组为33眼,两者间差异有统计学意义(P<0.05);盐酸丙美卡因组30眼SIT值小于5 mm,盐酸奥布卡因组为21眼,两者间差异无统计学意义(P>0.05)。结论盐酸丙美卡因较盐酸奥布卡因有更好的眼部耐受性,且测量的SIT值短于盐酸奥布卡因组,说明盐酸丙美卡因眼表麻醉效果可能要强于盐酸奥布卡因。Objective To observe the effects of two different topical anesthetics on Schirmer I test（SIT）. Methods A total of 84 patients（168 eyes,51 male,33 female） were examined.Two topical anesthetics,0. 5% proparacaine or 0. 4% oxybuprocaine used for once were applied on the right or left eyes randomly of a same patient. The irritation and conjunctival congestion,SIT results were observed and analyzed. Results Irritation in proparacaine group appeared in 15 eyes,which were 33 eyes in oxybuprocaine group,there was statistical difference（ P 〈0. 05）.Conjunctival congestion was observed in 54 eyes in proparacaine group,which in oxybuprocaine group were 39 eyes,there was statistical difference（P 〈0. 05）. The mean value of SIT in the proparacaine group was（7. 50 ± 5. 15） mm and（9. 71 ± 5. 46） mm in the oxyburpocaine group,there was significant difference between the two groups（P 〈0. 05）. SIT values less than 10 mm were obtained in 48 eyes in proparacaine group,which in oxybuprocaine group were 33 eyes,there was statistical difference（P〈 0. 05）. SIT values less than 5 mm were obtained in 30 eyes in proparacaine group,which in oxybuprocaine group were 21 eyes,there was no statistical difference（P 〉0. 05）. Conclusion Proparacaine has significantly better toleration than oxybuprocaine.SIT values in the proparacaine group are significantly lower than those in the oxybuprocaine group,which indicates that proparacaine hydrochloride may have a stronger anesthetic effect on the ocular surface than oxybuprocaine.

关 键 词：泪液分泌试验 盐酸丙美卡因 盐酸奥布卡因 表面麻醉 

分 类 号：R779.66[医药卫生—眼科]