胞磷胆碱在血管性认知损害中的治疗作用  

Therapeutic effect of citicoline in vascular cognitive impairment

作　　者：安福丽[1] 毛宇湘[1] 刘胜春[1] 

机构地区：[1]河北省中医院药剂科,石家庄050011

出　　处：《国际脑血管病杂志》2014年第9期691-694,共4页International Journal of Cerebrovascular Diseases

摘　　要：血管性认知损害是指所有与血管性疾病有关的认知损害综合征，包括从轻度认知损害到血管性痴呆在内的重度认知损害。胞磷胆碱是神经元细胞膜的重要组成成分磷脂酰胆碱生物合成的必需中间体。实验研究显示，胞磷胆碱在脑缺血中具有神经保护和神经修复作用。临床研究显示，胞磷胆碱有可能改善血管性认知损害患者的认知功能。Vascular cognitive impairment refers to all cognitive impairment syndromes associated with vascular diseases, including severe cognitive impairment from mild cognitive impairment to vascular dementia. Citicoline is a necessary intermediate of the phosphatidylcholine biosynthesis, an important component of the neuronal membranes. Experimental studies have shown that citicoline has neuroprotective and neurorepair effects in cerebral ischemia. Clinical studies have shown that citicoline may improve cognitive function in patients with vascular cognitive impairment.

关 键 词：认知障碍 脑缺血 胞苷二磷酸胆碱 神经保护药 

分 类 号：R741.02[医药卫生—神经病学与精神病学]