^(99m)Tc-HL91乏氧显像在恶性脑胶质瘤放疗前后的变化观察  

Observation on changes of ^(99m)Tc-HL91 hypoxia imaging before and after brain malignant gliomas with radiotherapy

作　　者：董方[1] 薛金才[2] 

机构地区：[1]甘肃省肿瘤医院放疗科,甘肃兰州730050 [2]甘肃省肿瘤医院头颈科,甘肃兰州730050

出　　处：《甘肃医药》2014年第10期737-739,共3页Gansu Medical Journal

基　　金：甘肃省技术研究与开发专项计划(项目编号:1205TCYA030)

摘　　要：目的:观察并分析恶性脑胶质瘤患者放疗前、后99mTc-HL91乏氧显像T/N比值的变化差异性。方法:对85例恶性脑胶质瘤术后患者,分别于放疗前、后进行99mTc-HL91 SPECT脑乏氧显像检测,测定早期相(注射造影剂后0.5小时)及延迟相(注射造影剂后5.0小时)的肿瘤区与周围正常脑组织放射性计数(ROI)比值T/N,将检测结果进行差异性比较。结果:放疗前、后99mTc-HL91SPECT脑乏氧显像延迟相T/N比值差异显著,有统计学意义(P<0.05)。且放疗后延迟相T/N均数值比放疗前延迟相T/N均数值小,提示均数值呈下降趋势。所有患者检测过程中均无任何主观不适和严重毒副作用。结论:放疗前后乏氧显像延迟相T/N数值变化差异有显著性,表明放疗杀死肿瘤细胞后,乏氧细胞再氧合,肿瘤氧合状态发生变化;从另一方面验证分次放疗可有效杀伤肿瘤细胞,为证实脑胶质瘤术后放疗可提高肿瘤治疗疗效提供依据。放疗后比放疗前延迟相T/N均数值小,提示放疗后乏氧状态呈下降趋势,证明放射治疗对肿瘤细胞有效。Objective：To study the T/N ratio difference and trend of 99mTc-HL91 hypoxia imaging before and after brain malignant glioma with radiotherapy. Methods： 85 postoperative patients with malignant glioma were detected 99mTc - HL91 SPECT hypoxia imaging before and after radiotherapy in which radioactive count （ROI） in the early phase （half an hour） and delayed phase （5 hours ） in the tumor area and normal tissue was tested. Results：T/N at delayed phase was statistical significance before and after radiotherapy in 99mTc - HLgl SPECT hypoxia imaging （P〈0.05）. T/N after radiotherapy at delayed phase was lower than before. All patients had no comfortable and serious toxic effect during the test. Conclusion：T/N at delayed phase was statistical significance before and after radiotherapy in 99mTc - HL91 SPECT hypoxia imaging, which indicates that the radiotherapy can kiU cancer cell and provides some scientific data for effect of radiotherapy on postoperative patients with malignant glioma. T/N after radiotherapy at delayed phase was lower than before, which shows that status of hypoxia declines after radiotherapy.

关 键 词：乏氧显像 恶性脑胶质细胞瘤 放射治疗 

分 类 号：R734.204[医药卫生—肿瘤]