多药转运蛋白与线粒体在难治性癫痫发病中作用的研究进展  

Progress of the multidrug transporter protein and mitochondria and their roles in refractory epilepsy

作　　者：周睿姣 王莉[1] 余巨明[1] 

机构地区：[1]川北医学院附属医院神经内科,四川南充637000

出　　处：《中华临床医师杂志（电子版）》2014年第18期135-138,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：难治性癫痫的耐药性研究已取得了一定的进展。近年发现,多药转运蛋白和线粒体的异常与难治性癫痫的发生存在密切的联系。文中介绍两种主要多药转运蛋白(P-糖蛋白、多药耐药相关蛋白)和线粒体的结构、功能以及线粒体基因的有关改变,并对其近年在难治性癫痫耐药中作用的研究进展作一综述。Research in the drug resistance of refractory epilepsy has made some progress. In reeent years, refractory epilepsy has been found to be highly related to multidrug transporter protein and mitochondria. The structures and functions of the two major multidrug transporter proteins （P-glyeoprotein, multidrug resistance-associated protein） as well as the mitochondria and the related changes of the mitochondrial genes were introduced and the progress of their roles in the refractory epilepsy were reviewed.

关 键 词：P糖蛋白 线粒体 难治性癫痫 多药转运蛋白 

分 类 号：R742.1[医药卫生—神经病学与精神病学]