血小板在肿瘤生长和转移中的作用  

Functions of platelets in tumor growth and metastasis

作　　者：张天嘉 党素英[2] 

机构地区：[1]上海交通大学口腔医学院,200025 [2]上海交通大学口腔医学院医学遗传教研室,200025

出　　处：《国际肿瘤学杂志》2014年第9期645-647,共3页Journal of International Oncology

基　　金：基金项目：国家自然科学基金（81200352）;上海交通大学医学院RBL教学项目（20138001）

摘　　要：血小板的数量和活性增加与肿瘤转移相关，血小板主要通过促进免疫逃避、黏附作用以及血管生成参与肿瘤转移进程。最新研究显示血小板与肿瘤细胞间的直接相互作用对肿瘤的转移也具有重要的促进作用。血小板促进肿瘤进展和转移的作用提示血小板可以作为肿瘤治疗的新靶点。Increases of platelet amount and activation are associated with tumor metastasis.Current studies reveal that platelets participate in the process of tumor metastasis via promoting immune escape,adhe-sion and angiogenesis.The direct interactions between platelets and tumor cells are also founded as an important determinant in metastasis.The functions of platelets in tumor progression and metastasis suggest that platelets could be served as new potential targets for cancer treatment.

关 键 词：血小板 肿瘤 肿瘤转移 

分 类 号：R730.2[医药卫生—肿瘤]