人胰腺癌中Livin及血管内皮生长因子的表达及其临床意义  

Expressions and clinical significances of Livin and vascular endothelial growth factor in human pancre-atic carcinoma

作　　者：薛栋[1] 赵海霞[1] 常刚[2] 李新军[3] 李梦宇[1] 成丕光[1] 张成德[1] 张同军[1] 

机构地区：[1]山东省滨州市人民医院肝胆外科,256610 [2]山东省滨州市人民医院外周介入科,256610 [3]山东省滨州市人民医院病理科,256610

出　　处：《国际肿瘤学杂志》2014年第9期700-703,共4页Journal of International Oncology

摘　　要：目的：探讨人胰腺癌组织中Livin与血管内皮生长因子（VEGF）的表达情况和临床意义。方法采用免疫组织化学法检测68例胰腺癌组织中Livin及VEGF蛋白的表达，并以44例癌旁组织作为对照。结果 Livin在胰腺癌组织及癌旁组织中的阳性表达率分别为73．5％和4．5％；Livin在44例癌组织及配对癌旁组织中的阳性表达率比较，差异有统计学意义（χ2＝48．137，P＜0．001）；VEGF在胰腺癌组织及癌旁组织中的阳性表达率分别为69．1％和13．6％；VEGF在44例癌组织及配对癌旁组织中的阳性表达率比较，差异有统计学意义（χ2＝29．147，P＜0．001）。Livin及VEGF蛋白的表达均与肿瘤分化程度（χ2＝6．061，P＝0．014；χ2＝6．592，P＝0．010）、临床TNM分期（χ2＝4．175，P＝0．041；χ2＝9．992， P＝0．002）、区域淋巴结转移（χ2＝11．731，P＝0．001；χ2＝12．002，P＝0．001）及神经浸润（χ2＝9．950， P＝0．002；χ2＝7．433，P＝0．006）有关。Spearman相关性分析表明Livin与VEGF在胰腺癌组织中的阳性表达呈正相关（r＝0．320，P＝0．008）。生存分析表明，Livin及VEGF 均是胰腺癌预后的独立因素。结论 Livin及VEGF参与了胰腺癌的发展、侵袭和转移，推测Livin可能通过上调VEGF促进肿瘤血管生成和肿瘤细胞迁移。Objective To investigate the expressions of Livin and vascular endothelial growth factor （VEGF）in pancreatic carcinoma and their cilinical significances.Methods The expressions of Livin and VEGF proteins were tested by immunohistochemistry in 68 cases of pancreatic carcinomas and 44 cases of adja-cent paracancerous tissues.Results The positive rates of Livin in pancreatic carcinomas and adjacent paracan-cerous tissues were 73.5% and 4.5% respectively,and the difference was statistically significant （χ2 =48.137,P＆lt;0.001）.The positive rates of VEGF in pancreatic carcinomas and adjacent paracancerous tissues were 69.1% and 13.6% respectively,and the difference was statistically significant （χ2 =29.147,P ＆lt;0.001）.The expressions of Livin and VEGF were related with tumor differentiation （χ2 =6.061,P=0.014;χ2 =6.592,P=0.010）,TNMstage （χ2 =4.175,P=0.041;χ2 =9.992,P=0.002）,lymph node metasta-sis （χ2 =11.731,P=0.001;χ2 =12.002,P=0.001）and neural invasion （χ2 =9.950,P=0.002;χ2 =7.433,P=0.006）.Significantly positive correlation was found between the expressions of Livin and VEGF by using Spearman correlation analysis （r=0.320,P=0.008）.Survival analysis showed that the expressions of Livin and VEGF were independent prognostic factors in pancreatic carcinoma.Conclusion Livin and VEGF involve in the development,migration and metastasis of pancreatic carcinoma.Livin may upregulate the expres-sion of VEGF,which may lead to the angiogenesis and migration in pancreatic carcinoma.

关 键 词：胰腺肿瘤 基因 血管内皮生长因子类 免疫组织化学 

分 类 号：R735.9[医药卫生—肿瘤]