乳腺癌旁正常腺体退化程度研究  

Study on lobular involution of glands around breast cancer

作　　者：徐雅莉[1] 孟云霄[2] 高云周[3] 孙强[1] 

机构地区：[1]中国医学科学院/北京协和医学院北京协和医院乳腺外科/协和转化医学中心,北京100730 [2]中国医学科学院/北京协和医学院北京协和医院病理科,北京100730 [3]中国医学科学院基础医学研究所病理室,北京100005

出　　处：《中华内分泌外科杂志》2014年第5期365-368,共4页Chinese Journal of Endocrine Surgery

基　　金：科技部十二五科技支撑计划课题（2014BAI08B03）

摘　　要：目的 明确乳腺癌旁腺体退化程度及乳腺内不同部位腺体退化一致性.方法 选择2010年12月1日至2011年12月1日北京协和医院乳腺外科乳腺癌保乳改良根治术22例,测量88张HE染色切片乳腺小叶面积及小叶内腺泡数量,评估乳腺小叶退化程度.应用两变量相关分析考察乳腺小叶面积和小叶内腺泡数量间相关性;应用方差分析、列联表分析和信度分析考察不同位置腺体退化程度一致性（P＜0.05）.结果 乳腺小叶平均面积（90 248.5±56 909.4） μm2,每个小叶平均含腺泡（25.68±18.86）个,乳腺小叶面积和小叶内腺泡数量具有显著相关性（Pearson r=0.78,P＜0.01）.乳腺癌保乳改良根治术患者癌旁腺体退化程度具有一致性（方差分析小叶面积19例无差异,小叶面积/腺泡数量18例无差异;Kappa系数=0.65;组内相关系数ICC=0.73）.结论 乳腺癌旁腺体退化不全,表现为乳腺小叶面积大及腺泡数量多,且2者具有相关性.乳腺癌旁不同位置腺体退化程度基本一致,单点退化程度能代表全乳腺情况.Objective To study lobular involution of tissues around breast tumor,and to assess the consistency of lobular involution of tissues from different parts of the breast.Methods 22 patients receiving breast conservation surgery in Breast Surgery Department of Peking Union Medical College Hospital from Dec.1 st,2010to Dec.1 st,2011 were collected.88 pieces of HE staining were measured in terms of lobular area and number of acini per lobular,and lobular involution was evaluated.Bivatiate correlation analysis was applied to explore correlation between lobular area and acini per lobular.ANOVA,crosstabs and reliability analysis were applied to explore involution consistency of different parts of breast （P ＜ 0.05）.Results The average area of lobuli was （90 248.5 ＋56 909.4） μm2 and the number of acini was 25.68 ± 18.86 per lobular.The lobular area and number of acini were correlated with each other significantly（Pearson r =0.78,P ＜ 0.01）.Involution status of different parts of breast had good consistency（for lobular area 19 cases showed no difference in ANOVA analysis and for lobular area/number of acini 18 cases showed no difference; Kappa coefficient =0.65; ICC =0.73）.Conelusions Lobuli around breast tumor have comparatively poor involution,with big lobuli and large number of acini,which are correlated with each other.Involution status of different parts of a breast has good consistency.Biopsy from one site to evaluate involution extent of the whole breast is practicable.

关 键 词：乳腺癌 保乳手术 腺体退化 

分 类 号：R737.9[医药卫生—肿瘤]