脑梗死患者hs-CRP FIB D-二聚体及血脂相关指标检测结果的分析  

Analysis of plasma hs-CRP,FIB,D-dimer and lipids related indicators in patients with cerebral infarction

作　　者：郑红云[1] 李艳[1] 李松[1] 

机构地区：[1]武汉大学人民医院检验科,湖北武汉430060

出　　处：《国际检验医学杂志》2014年第18期2439-2440,2443,共3页International Journal of Laboratory Medicine

基　　金：国家自然科学基金资助项目(81100959);国家临床重点专科建设项目[财社(2010)305号]

摘　　要：目的探讨血脂相关指标、超敏C反应蛋白(hs-CRP)、纤维蛋白原(FIB)和D-二聚体水平与脑梗死发病的相关性。方法选取脑梗死患者259例(脑梗死组),同期健康体检者210例作为对照组。采用酶比色法测定血脂相关指标[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白(Apo)A1、ApoB、ApoE]水平;采用荧光免疫干式定量法测定hs-CRP;用凝固法检测FIB;采用免疫比浊法测定D-二聚体水平。结果与对照组相比,脑梗死患病组TG、LDL-C、ApoA1、ApoE、hs-CRP、D-二聚体及FIB水平均显著升高(P<0.01),而HDL-C水平则显著降低(P<0.01),TC与ApoB水平差异无统计学意义(P>0.05)。结论炎症、血脂、凝血与纤溶系统可相互影响,并与脑梗死的发生和发展关系密切,联合检测有助于辅助诊断脑梗死。Objective To study the lipids related indicators ,high-sensitivity C-reactive protein（hs-CRP） ,FIB and D-dimer levels in cerebral infarction patients .Methods 259 cerebral infraction patients（cerebral infraction group） and 210 healthy individuals（con-trol group） were enrolled in the study .Plasma lipids related indicators such as TC ,TG ,HDL-C ,LDL-C ,ApoA1 ,ApoB ,ApoE levels were measured by enzymatic colorimetric assay .Quantitative fluorescence immunoassay was used to determine serum level of hs-CRP .FIB levels were determined by using coagulation method ,and D-dimer levels by using immune turbidimetric method .Results Compared with the control group ,the TG ,LDL-C ,ApoA1 ,ApoE and hs-CRP levels were significantly higher in the cerebral infarc-tion group（P〈0 .01） ,however ,the HDL-C level decreased significantly （P〈0 .01） .For TC and ApoB levels ,there were no statis-tical differences between the two groups（P〉0 .05） .Conclusion Lipids ,inflammation ,coagulation and fibrinolysis are closely relat-ed in the development of cerebral infarction ,and combined detection helps diagnose cerebral infarction .

关 键 词：脑梗死 血脂 超敏C反应蛋白 纤维蛋白原 D-二聚体 

分 类 号：R743.33[医药卫生—神经病学与精神病学]