急性脑梗死患者血浆Hcy hs-CRP vWF检测的临床意义  

Clinical significance of plasma Hcy hs-CRP and vWF determination in patients with acute cerebral infarction

作　　者：张琦[1] 耿洁[1] 赵建国[1] 张学齐[1] 李国森[1] 严炜[1] 张根利[1] 

机构地区：[1]天津中医药大学第一附属医院,天津300193

出　　处：《国际检验医学杂志》2014年第18期2444-2445,共2页International Journal of Laboratory Medicine

基　　金：天津市卫生局科技基金项目(2011KZ124)

摘　　要：目的探讨急性脑梗死患者血浆同型半胱氨酸(Hcy)与超敏C反应蛋白(hs-CRP)、血管性假血友病因子(vWF)水平的相关性及临床意义。方法选取急性脑梗死患者150例,按照其血浆Hcy增高程度不同分为3组。另外,选取同期健康体检者50例作为对照组,分别测定急性脑梗死患者和对照组健康者血浆hs-CRP、vWF及Hcy水平并进行组间比较,并对hs-CRP与Hcy、vWF与Hcy的检测结果进行相关性分析。结果急性脑梗死患者血浆hs-CRP、vWF及Hcy水平显著高于对照组(P<0.05);急性脑梗死患者血浆hs-CRP、vWF升高水平与Hcy升高水平呈正相关。急性脑梗死患者各组Hcy、hs-CRP、vWF水平均显著高于对照组(P<0.05)。结论血浆hs-CRP、vWF、Hcy可作为血管内皮损伤的标志物,这三项指标的联合检测可以为急性脑梗死早期诊断和治疗提供依据。Objective To investigate the correlation between plasma homocysteine （Hcy） and high sensitivity C-reactive protein （hs-CRP） ,Hcy and von Willebrand factor（vWF） in patients with acute cerebral infarction ,and to analyze their clinical significance . Methods 150 patients with acute cerebral infarction were enrolled in the study ,and were divided into 3 groups according to their plasma Hcy concentrations .Meanwhile 50 healthy people were recruited as control group .Plasma hs-CRP ,vWF and Hcy concentra-tions were determined and compared between groups .Then data correlation analysis was performed .Results In patients with acute cerebral infarction plasma hs-CRP ,vWF and Hcy concentrations were significantly higher than those in healthy control group （P〈0 .05） .Plasma Hcy concentrations in patients with acute cerebral infarction were positively correlated with plasma hs-CRP and vWF concentrations .Conclusion Hs-CRP ,vWF and Hcy are biomarkers of endothelial injury ,the combined detection of the three indica-tors might contribute to the early diagnosis and treatment of acute cerebral infarction .

关 键 词：急性脑梗死 同型半胱氨酸 超敏C反应蛋白 血管性假血友病因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]