UHRF1在肝细胞肝癌中的表达及意义  

Expression and Clinical Significance of UHRF1 in Hepatocellular Carcinoma

作　　者：施国明[1] 蔡加彬[1] 俞静娴 柯爱武[1] 董兆如[1] 张弛[1] 张鹏飞[1] 邱双健[1] 孙惠川[1] 周俭[1] 樊嘉[1] 

机构地区：[1]复旦大学附属中山医院肝外科,上海200032

出　　处：《中国临床医学》2014年第3期242-244,共3页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金项目(编号:81071741);上海市科委医学引导类项目(编号:114119a5000);教育部新教师基金项目(编号:20090071120025)

摘　　要：目的:探讨UHRF1(Ubiquitin-like,containing PHD and RING finger domains 1)在肝细胞肝癌(hepatocellular carcinoma,HCC)中的表达及其与临床病理特征的关系。方法:采用免疫组织化学方法检测556例HCC组织及其癌旁组织中UHRF1的表达,分析其与HCC患者临床病理特征的关系。结果:免疫组织化学结果显示,UHRF1蛋白阳性表达定位于HCC细胞核,UHRF1蛋白在HCC组织中的表达显著高于癌旁组织。HCC组织中UHRF1蛋白阳性表达率为59%,其表达与肿瘤大小(P<0.01)、肿瘤分化(P<0.05)和微血管侵犯(P<0.01)相关。结论:HCC中UHRF1的表达与其恶性表型相关,UHRF1可能参与HCC的侵袭和转移。Objective：To study the expression of UHRF1 and its relationships with the clinicopathological characteristics in hepatocellular carcinoma（HCC） .Methods ：The expression of UHRF1 was analyzed in 556 cases of tumor tissues and peritumor tissues of HCC by immunohistochemistry .The relationships of UHRF1 with the clinicopathological characteristics of HCC were assayed .Results：Immunohistochemistry showed that positive staining of UHRF1 located in the nucleus of HCC cells .The ex-pression levels of UHRF1 protein were higher in tumor tissues than in peritumor tissues .HCC patients with positive expression of UHRF1 protein accounted for 59% of the whole cohort .The expression of UHRF1 protein was significantly correlated with the size of tumor （ P〈0 .01） ,differentiation （P〈0 .05） and microvessel invasion（P〈0 .01） .Conclusions ：The overexpression of UHRF1 is correlated with the malignant phenotypes of HCC and probably implicated in the invasion and metastasis of HCC .

关 键 词：肝细胞肝癌 UHRF1 临床病理特征 表观遗传学 

分 类 号：R735.7[医药卫生—肿瘤]