黄芪、大黄配伍对慢性肾功能衰竭大鼠血生化及抗氧化能力的影响  

Effects of compatibility of rhubarb and astragalus mongholicus on blood biochemistry and antioxidant of chronic renal failure rats

作　　者：尹翠翠[1] 杨勇[1] 容蓉[1] 

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《山西中医学院学报》2014年第2期21-23,共3页Journal of Shanxi College of Traditional Chinese Medicine

摘　　要：目的:观察中药黄芪、大黄配伍对慢性肾功能衰竭(CRF)大鼠血生化及抗氧化能力的影响。方法:将大鼠随机分为正常组、模型组、黄芪组、大黄组、黄芪大黄配伍组,采用3%腺嘌呤灌胃制作CRF大鼠模型,实验5 w后分别采血检测血肌酐(Cr)、尿素氮(UREA)、胆固醇(CHOL)、甘油三酯(TG)、钙(Ca)、磷(P)等生化指标,并检测超氧化物歧化酶(SOD)、过氧化脂质(LPO)等指标。结果:与正常组比较,模型组大鼠Cr、UREA、P及SOD含量明显升高(P<0.01);与模型组比较,黄芪大黄组、大黄组、黄芪组大鼠血浆P、LPO明显降低(P<0.01),黄芪大黄组UREA、Cr、CHOL及TG均降低,但差异无统计学意义。结论:黄芪与大黄配伍对CRF有较好的治疗效果,其药理学机制可能与降低CRF大鼠血浆中的UREA、Cr,消除有害自由基等有关。Objective： To observe effects of compatibility of rhubarb and astragalus mongholicus on blood biochemistry and antioxidant of rats with chronic renal failure. Methods ：Rats were divided into normal group,model group,astragalus mongholicus group,rhubarb group,astragalus mongholicus and rhubarb group randomly. Chronic renal failure rat models were induced by 3% adenine with intragastric administration. Successive medication for 5 weeks,levels of creatinine（Cr）, urea nitrogen（UREA）,cholesterol（CHOL）,triglycerides（TG）,calcium（Ca）,phosphorus（P）as well as SOD and lipid per- oxidation （LPO） in serum were detected. Results：Compared with normal group,levels of Cr,UREA,P and SOD were in- creased in model group （P〈0.01）. The levels of P and LPO in rhubarb group,astragalus mongholicus group,rhubarb and astragalus mongholicus group were lower than those in model group（P〈0.01 ）. Compared with model group,levels of URE- A.Cr,CHOL and TG were declined in rhubarb and astragalus mongholicus group,but there was no significant difference. Conclusion ： Compatibility of rhubarb and astragalus mongholicus has therapeutic effect on chronic renal failure. Its phar- macological basis may be related to decreasing levels of UREA,Cr, clearing harmful free radicals.

关 键 词：大黄 黄芪 配伍 慢性肾功能衰竭 血生化 抗氧化能力 

分 类 号：R285.5[医药卫生—中药学]