痛觉中枢敏感化对偏头痛患者脑血流动力学的影响  

The effect of pain central sensitization on migrainal patients' cerebral haemedynamics

作　　者：张家君[1] 姜岳梅 赵晓霞[3] 牛敬忠[4] 张颜波[4] 

机构地区：[1]泰山医学院附属医院超声科,山东泰安271000 [2]泰安荣军医院,山东泰安271000 [3]山西省人民医院神经内科,山西太原030012 [4]泰山医学院附属医院神经内科,山东泰安271000

出　　处：《泰山医学院学报》2014年第8期717-719,共3页Journal of Taishan Medical College

基　　金：山东省自然基金(ZR2012HQ014);泰安市科技发展计划(20123060)

摘　　要：目的观察痛觉中枢敏感化对偏头痛患者脑血流动力学的影响。方法随机分为正常对照组、偏头痛组,应用CA症状自评量表,将偏头痛患者分为无CA组和CA组。应用美国GE ViVid E9超声诊断仪,对偏头痛患者发作后2h进行脑血流动力学测定。结果在入组的108例患者中,偏头痛发病后2 h,72例患者出现CA,出现率为66.7%,25、20、27人分别出现轻、中、重CA,出现率分别为23.1%、18.5%、25.1%。72例偏头痛患者有CA,36例患者无CA。无CA、CA患者脑平均血流速度与正常对照组相比,血流速度显著增加,P<0.01;CA患者与无CA患者相比,血流速度明显增加,P<0.01。结论偏头痛患者存在脑血流动力学异常,脑平均血流速度增加,在偏头痛中枢敏感化患者中更加显著。Objective：To explore the effect of pain central sensitization on migrainal patientsˊ cerebral haemedynamics. Method：The patients were randomly divided into control group and migraine group. The migrainal patients were divied into CA group and Not - have CA group using CA symptom checklist. The patientsˊcerebral haemedynamics 2 hours after the at-tack of migraine wered measured using American Ge ViVid e9 ultrosonic diagnostic equipment. Results：Among all the 108 patients,2 hours after the attack of migraine,CA emerges in 72 cases,the occurrence rate is 66. 7% ,25 cases are of slight CA degree,20 cases moderate degree and 27 cases severe degree,the occurrence rate is 23. 1% ,18. 5% and 25. 1% respectively. 72 cases have CA while 36 cases donˊt have. Comapred with control group,the average cerebral blood speed of not - have CA,CA patients increases significantly,p 〈 0. 01;Comapred with not - have CA patients,the blood speed of CA patients increases sharply,p 〈 0. 01. Conclusion：Cerebral haemedynamics abnormality exists in migrainal pq-tients,and the average cerebral blood speed increases,which is more significant in central sensitization of migraine.

关 键 词：偏头痛 加巴喷丁 中枢敏感化 血流动力学 

分 类 号：R747.2[医药卫生—神经病学与精神病学]