广东省老年人膳食维生素C摄入量与髋骨骨折关系的病例-对照研究  

DIETARY INTAKE OF VITAMIN C AND RISK OF HIP FRACTURE IN ELDERLY CHINESE IN GUANGDONG: A CASE-CONTROL STUDY

作　　者：孙丽丽[1] 薛文琼[1] 曹文婷[1] 樊帆[1] 谢海丽[1] 陈裕明[1] 

机构地区：[1]中山大学公共卫生学院医学统计与流行病学系,广州510080

出　　处：《营养学报》2014年第5期430-434,共5页Acta Nutrimenta Sinica

基　　金：国家自然科学基金(No.30872100;No.81072299)

摘　　要：目的探讨老年人膳食维生素C（VC）摄入与髋骨骨折（HF）的关系。方法采用1：1配对病例对照研究,通过面对面访谈方式于2008年1月至2013年7月,对广东省4家医院726名55~80岁老年HF病人及与性别、年龄（±3岁）配对的726名对照者进行问卷调查。调查内容包括：对象一般情况、父母骨折史、生活习惯等。采用含79个条目的食物频数问卷调查研究对象既往一年详细的膳食摄入情况。结果单因素logistic回归分析结果显示,膳食摄入维生素C（VC）和HF发生风险呈负相关（趋势检验P〈0.001）。在校正人口及社会经济因素、家族史、体质指数和健康相关行为等因素以及其他一些膳食因素后,上述负性关联仍然存在（P〈0.001）。和VC摄入量最低四分位组相比,第2~4分位组的OR值（95%置信区间）分别为0.48（0.34~0.67）、0.47（0.33~0.67）和0.30（0.20~0.44）。分层分析显示,在补充钙制剂的人群中膳食维生素C和HF的负相关关联更强。结论老年人膳食维生素C摄入越高HF的风险越低。Objective To examine the association between dietary intake of vitamin C （VC） and risk of hip fracture in elderly Chinese. Methods This 1：1 matched case-control study involved 726 elderly Chinese with hip fracture and 726 sex- and age-matched （：k 3 years） controls from 4 hospitals in Guangdong province, recruited between January 2008 and July 2013. Face-to-face interviews were conducted to determine habitual dietary intake based on a 79-item food frequency questionnaire and information on various covariates. Results In the univariate logistic regression analysis, a significant inverse association was observed between the dietary VC intake and risk of hip fracture （P-trend： 〈0.001）. After adjustment for potential covariates in demography, socioeconomics, health behaviors, BMI and relevant dietary factors, the dose-dependent inverse associations remained significant （P-trend： 〈0.001）. Odds ratios （95%CI） of hip fracture for the quartile 2-4 （vs. lowest） of VC intake were 0.48 （0.34-0.67）, 0.47 （0.33-0.67） and 0.30 （0.20-0.44）, respectively. Stratified analysis showed that the favorable association was more pronounced among users of calcium supplement than in non-users. Conclusion Higher dietary intake of vitamin C is associated with lower risk of hip fracture in elderly Chinese.

关 键 词：膳食维生素C 髋骨骨折 病例对照研究 

分 类 号：R151.4[医药卫生—营养与食品卫生学]