DF方案联合顺铂腹腔热灌注化疗治疗晚期胃癌的临床研究  

Treatment of Gastric Cancer with DF Regimen Combined with Hyperthermic Intraperitoneal Perfusion Chemotheraphy with Cisplatin

作　　者：吴稚冰[1,2] 吴侃[1] 李夏东[1] 景赛赛[1] 郑智爽 唐荣军[2] 赖建军[2] 王佳浩 

机构地区：[1]杭州市第一人民医院放疗科,杭州310006 [2]杭州市肿瘤医院肿瘤热疗中心,杭州310006

出　　处：《科技导报》2014年第30期55-58,共4页Science & Technology Review

摘　　要：为观察和比较多西他赛周方案给药联合5-氟尿嘧啶(5-FU)和顺铂(DDP)静脉化疗与多西他赛(DOC)、5-氟尿嘧啶静脉给药联合顺铂腹腔热灌注,治疗晚期胃癌患者的初步疗效和副反应,将90例晚期胃癌患者,随机分入多西他赛、5-氟尿嘧啶和顺铂静脉化疗组或多西他赛、5氟尿嘧啶静脉化疗联合顺铂腹腔热灌注化疗组,静脉化疗组45例,热灌注化疗组45例。研究表明,静脉化疗组有效率为44.4%(20/45),热灌注化疗组为66.7%(30/45),其中完全缓解(CR)1例,有统计学差异(P=0.038);临床受益反应(CBR)评估,静脉化疗组有效率为64.4%(29/45),热灌注化疗组为82.2%(37/45),差异有统计学意义(P=0.0458);两组副反应主要为骨髓抑制,胃肠道反应,神经毒性等,无统计学差异。多西他赛周方案、5-氟尿嘧啶联合顺铂腹腔热灌注化疗方案治疗晚期胃癌近期疗效优于单存静脉化疗,两组副反应相似,耐受性良好。This study aims to observe and compare the efficacy and side effect of weekly docetaxel combined with 5-fluorouracil and cisplatin intravenous treatment and weekly docetaxel plus 5-fluorouracil intravenous combined with intraperitoneal perfusion （CHPP） with cisplatin treatment. Ninety patients with advanced gastric cancer were randomized into intravenous chemotherapy group （45 patients） who received docetaxel 36 mg/m2, iv, lwk×3wk, CF 200 mg/m2, iv, dl-5, 5-Fu 500 mg/m2, iv, dl-5, DDP 25 mg/m2, iv, dl-3, repeated every four weeks for two cycles and intravenous chemotherapy plus CHPP group （45 patients） who received doeetaxel 36 mg/m2, iv, lwk× 3wk, CF 200 mg/m2, iv, dl-5, 5-FU 500 mg/m2, iv, dl-5, DDP 75 mg/m2, CHPP, dl, and abdomen hyperthermia treatment with radiofrequency. The results show that all patients were assessable for response in intravenous chemotherapy group and CHPP group. The overall response rate of intravenous chemotherapy group was 44.4%. The response rate of CHPP group was 66.7%, including one CR. There was statistical difference between two groups （P=0.038）. The clinical beneficial response （CBR） in intravenous chemotherapy group and CHPP group were 64.4% and 82.2%, respectively. There was apparent statistical difference （P=0.0458）. The major toxieities were myelosuppression, nausea/vomiting and neurotoxieity. There was no significant difference in side effect between the two groups. Docetaxel administered by weekly infusion plus 5-fluorouraeil combined with hypertbermie intraperitoneal perfusion chemotherapy with cisplatin in the treatment of advanced gastric cancer is more effective than intravenous treatment. The side effect of two groups was similar. CHPP therapy was well tolerated.

关 键 词：晚期胃癌 多西他赛 5氟尿嘧啶 顺铂 腹腔温热灌注化疗 

分 类 号：R735.2[医药卫生—肿瘤]