大功率微波肿瘤热化疗多中心临床分析  

Clinical Analysis of Multi-center for Tumor Chemotherapy Combined with High Power Microwave-hyperthermia

作　　者：章岳山 郭方[2] 唐铁钢 黄建瑾[4] 王力军[5] 杜兴[6] 

机构地区：[1]上海市普陀区利群医院,上海200333 [2]中国科学院上海高等研究院肿瘤靶向治疗实验室,上海201210 [3]湘潭市中心医院,湘潭411100 [4]浙江大学附属第二医院,杭州310009 [5]邢台医学高等专科学校附属第二医院,邢台054000 [6]湖南省肿瘤医院,长沙410006

出　　处：《科技导报》2014年第30期59-62,共4页Science & Technology Review

摘　　要：通过对使用大功率微波作为热源的亚高温热化疗与常规化疗的对比观察,探讨了肿瘤热化疗疗效和不良反应与常规化疗之间的差异。对13608例使用大功率微波热疗机实施全身亚高温热疗配合化疗患者与15408例常规化疗患者的疗效和不良反应进行对比,分析了微波场亚高温条件下化疗的机理及热疗温度、治疗时间、疗程与疗效的关系,以及微波热化疗疗效及不良反应与常规化疗之间的差别。结果显示,大功率微波热源的亚高温热化疗有效率为81.15%,常规化疗有效率为39.03%,且微波热化疗所致的不良反应率较常规化疗低。表明大功率微波热化疗治疗肿瘤的疗效明显优于常规化疗,而且减轻患者化疗的不良反应,是肿瘤治疗的有效手段。This paper compares the difference in efficacy of tumor hyperthermia combined with chemotherapy and conventional chemotherapy and their adverse reactions through comparative observation. The former 13608 cases underwent whole body mild hyperthermia combined with chemotherpy with high-powered microwave hyperthermia machine, and the latter 15408 cases underwent standard chemotherapy. We analyzed the mechanism of chemotherapy under microwave hyperthermia and the relationships among temperature control, time, course, and efficacy of treatment. The effective rate of treatment of high-powered hyperthermia combined with chemotherapy was 81.15%, and that of standard chemotherapy was 39.03%. The results show that the curative effect of the former is significantly better than that of the latter, and the adverse reactions were apparently reduced. Hyperthermia is becoming an effective therapeutic method for tumors.

关 键 词：微波 亚高温热疗 化疗 恶性肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]