序贯疗法与三联疗法根除幽门螺杆菌疗效对比研究  

The contrastive study on the clinical effect of Sequential therapy and tripal treatment for eradication of Helicobacter Pylori

作　　者：傅海燕[1,2] 姚萍[1] 张伟平 

机构地区：[1]新疆医科大学第一附属医院消化科,乌鲁木齐830054 [2]乌鲁木齐市友谊医院消化科,乌鲁木齐830049 [3]乌鲁木齐军区总医院消化科,乌鲁木齐830000

出　　处：《新疆医科大学学报》2014年第11期1480-1482,1486,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(30873472)

摘　　要：目的比较序贯疗法与三联疗法根除幽门螺杆菌(H.pylori,Hp)的临床疗效。方法选择2013年10月—2014年3月新疆医科大学第一附属医院消化内科证实存在Hp感染需要治疗的新疆地区194例患者,随机分为两组:序贯疗法组(99例),前5天:埃索美拉唑肠溶片40mg+阿莫西林分散片1 000mg,每日2次,后5天:埃索美拉唑肠溶片40mg+克拉霉素片500mg+呋喃唑酮片100mg,每日2次。三联疗法组(94例):埃索美拉唑肠溶片40mg+阿莫西林分散片1 000mg+克拉霉素片500mg,每日2次,疗程均10d。比较两组患者Hp根除率、不良反应发生率。结果序贯疗法组及三联疗法组Hp根除率分别为87.88%、81.05%,差异有统计学意义(P=0.031)。两者组患者不良反应发生率分别为6.1%和8.4%,差异无统计学意义。患者在序贯疗法组中Hp根除率明显高于维吾尔族和其他少数民族,差异有统计学意义。结论在新疆地区,序贯疗法较三联疗法Hp根除率高,安全性相似。Objective To compare the clinical effect of sequential therapy and tripal treatment for eradication of Helicobacter Pylori （Hp）.Methods 194 cases with Hp infection between October 2013 and March 2014 were selected from Department of Gastroenterology of the First Affiliated Hospital of Xinjiang Medical University.They were randomly divided into two groups：the sequential treatment group （99 ca-ses）and Triple therapy group （94 cases）.The patients in the sequential treatment group were given Es-omeprazole enteric soated tablets 40 mg＋Anoxicllin Dispersible Tablets 1 000 mg,twice a day in the first five days;and Esomeprazole enteric soated tablets40 mg＋Clarithromycin tablets 500 mg＋Furazolidone Tables 100 mg,Twice a day in the last five days.The patients in the triple therapy group were given Es-omeprazole enteric soated tablets 40 mg＋Anoxicllin Dispersible Tablets 1 000 mg＋Clarithromycin tablets 500 mg,twice a day,for 10 days as a course of treatment.Then we compared the rate of eradication and the incidence of adverse reactions or side effect between two groups.Results The rate of eradication of Hp in sequential therapy group and the triple therapy group was 87.88%,81.05%,and the difference was sta-tistically significant （P =0.031）.The incidence of adverse reactions in both groups was 6.1% and 8.4% re-spectively,and the difference was not statistically significant.In the sequential therapy group patients Hp eradication rate was significantly higher than that in the Uighur and other minorities,the difference was statistically significant.Conclusion The rate of eradication of H.Pylori in sequential treatment was higher than that in triple therapy in Xinjiang.The safety of two therapies is the same.

关 键 词：幽门螺旋杆菌 序贯疗法 三联疗法 

分 类 号：R57[医药卫生—消化系统]