抗胃癌多药耐药性研究进展  

Research Progress in Anti-Multidrug Resistance of Gastric Carcinoma

作　　者：牛春丽[1] 彭芳[1] 

机构地区：[1]大理学院药学与化学学院,云南大理671000

出　　处：《医学综述》2014年第19期3523-3526,共4页Medical Recapitulate

摘　　要：胃癌是威胁人类健康的消化道恶性肿瘤之一,其发病率和病死率均较高。胃癌多药耐药性(MDR)的产生是化疗失败的主要原因。MDR是指肿瘤细胞对一种抗肿瘤药物产生耐药后,同时对化学结构及作用机制不同的抗肿瘤药物亦产生交叉耐药现象。近年来,为提高化疗的有效性,许多科研人员从多种途径、多个靶点、多种方式深入研究MDR的发生机制,以寻求高效、低毒的逆转剂。Gastric carcinoma is one of the the digestive tract malignant tumor threatening human health,with high incidence and mortality.Gastric carcinoma multidrug resistance（MDR） is the main cause of failure of chemotherapy.MDR refers to the multidrug resistance to different antitumor drugs of different chemical structure and mechanisms of tumor cells after becomeingresistant to one antitumore drug.In recent years,in order to improve the effectiveness of the chemotherapy,many researchers are conducting in-depth study on the mechanisms of multidrug resistance from a variety of ways,multiple targets,and multiple methods,to find agents with high efficiency and low toxicity to reverse MDR.

关 键 词：胃癌 多药耐药性 逆转剂 

分 类 号：R730.53[医药卫生—肿瘤]