肝素类药物防治阿尔采末病的研究进展  

Research progress on the effects of heparins on Alzheimer's disease

作　　者：郝丽娜[1] 赵孝林[1] 吴学新[1] 

机构地区：[1]山东大学齐鲁儿童医院药学部,山东济南250022

出　　处：《药学研究》2014年第11期657-660,共4页Journal of Pharmaceutical Research

摘　　要：本文分析了阿尔采末病(AD)的病理机制,对肝素类药物神经保护机制的进展进行了综述。阐明了肝素类药物可通过调节IP3受体介导的细胞内钙释放,影响淀粉样蛋白(Aβ)沉积及其毒性、调节tau蛋白的磷酸化状态,保护胆碱能神经元等发挥神经保护作用,从而延缓AD的发生与发展。This paper analyzed the pathological mechanisms of AD,reviewed the progress of the mechanisms of the neu-roprotective effect of heparin and its derivatives,clarified that heparin and its derivatives had neuroprotective effects through regulating IP3Rs-mediated intracellular calcium release,inhibiting Aβdeposition and Aβ-induced toxicity,regulating the tau protein phosphorylation state,and protecting cholinergic neurons,thereby delayed the occurrence and development of AD.

关 键 词：肝素 阿尔采末病(AD) 细胞内钙 淀粉样蛋白 TAU蛋白 胆碱能神经元 

分 类 号：R749[医药卫生—神经病学与精神病学]