蜘蛛抗菌肽研究进展  

Advances in spider antimicrobial peptides

作　　者：唐兴[1] 陈连水[1] 李江[1] 

机构地区：[1]东华理工大学化学生物与材料科学学院,南昌330013

出　　处：《生命科学》2014年第10期1090-1095,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31201718);江西省自然科学基金项目(20114BAB214015;20142BAB204011);江西省教育厅青年科学基金项目(GJJ12389);东华理工大学博士科研启动基金项目(DHBK1008)

摘　　要：蜘蛛活性多肽研究主要集中于蜘蛛毒液中作用于离子通道的神经毒素多肽。但近年来,一些蜘蛛抗菌肽不断被分离纯化,其结构和抗菌活性也被广泛深入研究,这将成为蜘蛛活性多肽研究领域的一个新热点。在蜘蛛毒液和血液中,存在不同种类的抗菌肽,其多肽长度、结构、抗菌作用各不相同。而且,有些抗菌肽甚至具有抗肿瘤作用。概述了蜘蛛抗菌肽在结构和功能方面的研究进展。Researches in spider active peptides are mainly focused on venom peptides that affect neuronal ion channels. However, in recent years, some spider antimicrobial peptides have been isolated and purified, and their structures and antibacterial activities have been widely and deeply studied. Spider antimicrobial peptides will be a new hotspot in this field. Various antimicrobial peptides are isolated from spider venom and blood with different peptide length, structure, and antibacterial effect. Moreover, some spider antimicrobial peptides exhibit cytotoxic activity against tumor cells. This review presents the research progress on structure and function of spider antimicrobial peptides.

关 键 词：蜘蛛 活性多肽 抗菌肽 肿瘤 

分 类 号：Q516[生物学—生物化学] Q71