肝细胞性肝癌血清中MIF、IL-17、IL-10的检测及其临床意义  

作　　者：钱夷婷[1] 吴婷婷[1] 

机构地区：[1]苏州大学附属第一医院消化科,江苏215006

出　　处：《当代医学》2014年第30期51-52,共2页Contemporary Medicine

摘　　要：目的检测肝细胞性肝癌血清中巨噬细胞游走抑制因子(macrophage migration inhibitory factor,MIF)、白细胞介素-17(interleukine-17,IL-17)、白细胞介素-10(interleukine-10,IL-10)的含量,并探讨其临床意义。方法选择50例肝细胞性肝癌患者设为观察组,将30例同期健康体检者设为对照组。采用酶联免疫吸附(ELISA)法检测2组血清中MIF、IL-17、IL-10的水平。结果观察组MIF、IL-17水平均显著高于对照组[(105.41±20.28)vs(23.25±8.81),(88.84±22.74)vs(24.06±11.36),t=31.263、25.668,P<0.05];观察组IL-10水平显著低于对照组[(97.58±19.26)vs(242.27±64.79),t=-60.589,P<0.05]。结论血清中MIF、IL-17、IL-10的含量异常与肝细胞性肝癌关系密切,对临床诊断有指导意义。Objective To study the clinical value of detection of the serum levels of MIF、IL-17 and IL-10 in the early diagnosis of hepatocellular carcinoma.Methods 50 patients with hepatocellular carcinoma and 30 health examination participants were included. The serum levels of MIF、IL-17 and IL-10 were measured by ELISA.Results Compared with healthy controls, MIF、IL-17 and IL-10 had signiifcant difference in hepatocellular carcinoma patients[（105.41＆#177;20.28）vs（23.25＆#177;8.81）, （88.84＆#177;22.74）vs（24.06＆#177;11.36）, （97.58＆#177;19.26）vs（242.27＆#177;64.79）,t=31.263、25.668、-60.589, P〈0.05）].Conclusion Serum levels of MIF、IL-17 and IL-10 is closely related with hepatocellular carcinoma and the detection of MIF、IL-17 and IL-10 had the guidance signiifcance for clinical diagnosis.

关 键 词：肝细胞性肝癌 MIF IL-17 IL-10 

分 类 号：R735.7[医药卫生—肿瘤]