无配体碘化亚铜催化杂环硫醇与碘代芳烃的C-S偶联反应研究  

Study on Ligand-free CuI-catalyzed C-S Cross-coupling of Heterocyclic Thiols with Aryl Iodides

作　　者：方淑莹 何国珍[1] 金明[1] 韩世清[1] 

机构地区：[1]南京工业大学生物与制药工程学院,江苏南京211816

出　　处：《化学世界》2014年第10期605-608,611,共5页Chemical World

摘　　要：在120℃DMF溶液中,采用10mol%CuI作催化剂,200mol%Na2CO3作碱进行C-S偶联反应,合成了一系列杂环硫化物。该方法无需任何配体,同时具有经济、高效等特点。产物的结构经1 H NMR、13C NMR、MS和元素分析证实。The ligand-free copper-catalyzed cross-coupling of heterocyclic thiols with aryl iodides was reported.The reaction was carried out in the presence of 10mol%CuI and 200mol% Na2CO3 in DMF at 120℃.A variety of heterocyclic sulfides were prepared with high selectivity and yield.The CuI catalyst was ligand-free,economical and effective.The structures of the products were characterized by 1 H NMR、13 C NMR、MS and elemental analysis.

关 键 词：铜催化 C-S偶联反应 碘代芳烃 杂环硫醇 

分 类 号：O625.6[理学—有机化学]