LAIR-1与TGF-β在口腔扁平苔藓患者外周血中表达的相关性研究  

Correlation of LAIR-1 and TGF-β expression in the peripheral blood of OLP patients

作　　者：张立荟[1] 李言君[1] 于平 付爱丽[3] 薛江楠[4] 刘玉三[1] 

机构地区：[1]滨州医学院附属医院口腔内科,256603 [2]烟台市口腔医院 [3]解放军107医院 [4]滨州医学院

出　　处：《实用口腔医学杂志》2014年第6期760-763,共4页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:81273200)

摘　　要：目的:研究LAIR-1和TGF-β在口腔扁平苔藓(OLP)患者外周血中的表达情况,探讨LAIR-1和TGF-β对OLP患者免疫功能的影响。方法:采用流式细胞术检测LAIR-1在OLP患者(n=22)和健康人(n=22)外周血Treg上的表达水平,ELISA检测外周血TGF-β的水平。结果:OLP患者外周血CD4+Foxp3+Treg上LAIR-1阳性率高于健康人,TGF-β的水平亦高于健康人,LAIR-1在CD4+Foxp3+Treg上的表达水平和TGF-β的水平呈正相关(r=0.43,P<0.05)。结论:LAIR-1和TGF-β在OLP患者外周血中表达上调,提示LAIR-1和TGF-β可能参与了OLP的发病。Objective： To investigate the expression of LAIR-1 on Treg cells and TGF-β in the peripheral blood of patients with oral lichen planus（OLP）. Methods： The peripheral blood was obtained from 22 OLP patients and 22 healthy controls. Flow cytometry was used to evaluate the proportion of LAIR-1 on CD4^＋Foxp3^＋Treg cells,and the level of TGF-β was measured by ELISA. Results： In the peripheral blood of OLP patients,the proportion of LAIR-1 on CD4^＋Foxp3^＋Treg cells and TGF-β content were significantly higher than those of the healthy controls（P〈0. 05）,The proportion of LAIR-1 on CD4＋Foxp3＋Treg cells was positively correlated with the level of TGF-β（r=0. 43,P〈0. 05）. Conclusion： The high expression of LAIR-1 on CD4＋Foxp3＋Treg cells and TGF-β in the peripheral blood of OLP patients may be responsible for the pathogenesis of OLP.

关 键 词：口腔扁平苔藓 调节性T细胞 LAIR-1 TGF-Β 流式细胞术 ELISA 

分 类 号：R781.5[医药卫生—口腔医学]