miR-31在肿瘤中预后作用的meta分析及机制  

Meta-analysis and associated mechanism on prognostic role of miR-31 in carcinomas

作　　者：付文博[1] 宋亚芹 杨兰[2] 朱建波[2] 魏育涛[3] 

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]石河子大学医学院病理科,新疆石河子832000 [3]石河子大学医学院第一附属医院心胸外科,新疆石河子832000

出　　处：《国际检验医学杂志》2014年第20期2729-2731,共3页International Journal of Laboratory Medicine

基　　金：国家自然科学基金资助项目(81260301);国家自然科学基金资助项目(81460059);兵团卫生科技-兵团博士基金(2014BB019)

摘　　要：目的综合评价miR-31与肿瘤预后之间的关系,探讨其相关机制。方法仔细检索美国国立图书馆（PubMed）,荷兰医学文摘（EMBASE）以及ISI Web of Science数据库与miR-31相关肿瘤预后文献,提取预后数据风险比（HR）和95%可信区间（95%CI）,并对预后数据进行合成分析。结果共有7篇研究符合入选标准,累积病例2 012例;Meta分析显示,肿瘤患者miR-31表达降低预后不良（HR=0.784,95%CI：0.630~0.974）;而亚组分析中采用多变量分析及中国人群的研究合成结果分别为3.512（95%CI：1.797~6.865）、1.574（95%CI：1.062~2.333）,提示miR-31表达升高预后不良;miR-31在消化系统中则无统计学意义（P〉0.05）。结论 miR-31在肿瘤中的预后作用可能具有组织及地域特异性,具备作为新型标记物的潜力。Objective To synthetically evaluate the relationship between miR-31 and the prognosis of carcinoma and to investi-gate its related mechanism.Methods The correlative literatures of tumor prognosis were retrieved from the electronic databases PubMed,EMBASE and ISI Web of Science.The pooled hazard ratios （HRs）and 95% confidence interval（95%CI ）were extracted. The prognostic data were performed the synthesis analysis.Results A total of 7 trials conformed to the inclusion criteria including accumulated 2 012 cases of carcinoma.Meta-analysis revealed that the decrease of miR-31 expression in the tumor patients had the poor prognosis （HR=0.784,95%CI ：0.630-0.974）;in the subgroup analysis,the synthesis results adopting the multivariable a-nalysis and China subjects were 3.512 （95%CI ：1.797-6.865）and 1.574 （95%CI ：1.062-2.333）,which indicating that the in-crease of miR-31 expression predicted the poor prognosis;miR-31 had no statistical significance in the digestive system （P 〉0.05）. Conclusion The prognostic role of miR-31 may possess the histological and regional specificity and has the potential as a novel marker.

关 键 词：肿瘤 miR-31 预后 肿瘤标记物 META分析 

分 类 号：R730.2[医药卫生—肿瘤]