6种肿瘤标志物联合检查对肺癌的诊断价值  

Diagnostic value of combined detection of six kinds of tumor markers on lung cancer

作　　者：贺望娇[1] 范柳青[1] 

机构地区：[1]广西医科大学第四附属医院柳州市工人医院检验科,广西柳州545005

出　　处：《国际检验医学杂志》2014年第20期2746-2748,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨肿瘤标志物神经特异性烯醇化酶(NSE)、细胞角蛋白(CYFRA21-1)、癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原153(CA153)和铁蛋白(Ferritin)对肺癌的诊断价值。方法采用电化学发光法分别检测151例肺癌(肺癌组)、100例肺良性疾病患者(肺良性疾病组)及50例健康对照组的血清NSE、CYFRA21-1、CEA、CA125、CA153、Ferritin水平并进行分析。结果肺癌组患者6种肿瘤标志物水平明显高于肺良性疾病组和健康对照组,差异有统计学意义(P<0.05)。小细胞肺癌的NSE水平高于鳞癌和腺癌,差异有统计学意义(P<0.05),而鳞癌和腺癌CYFRA21-1水平高于小细胞肺癌,差异有统计学意义(P<0.05)。6种肿瘤标志物中NSE的灵敏度最高,为82.8%。6项肿瘤标志物中3项阳性时,肺癌组阳性率较高,假阳性显著降低。结论血清肿瘤标志物的水平和阳性率与肺癌的病理类型有关。联合检测血清肿瘤标志物可提高早期诊断肺癌的灵敏度和特异度,首选CEA、NSE和CYFRA21-1 3种肿瘤标志物联合检测。Objective To investigate the value of serum tumor markers neuron specific enolase （NSE）,cytokeratin 19 fragment （CYFRA21-1）,carcinoembryonic antigen （CEA）,carbohydrate antigen 125 （CA125 ）,carbohydrate antigen 153 （CA153）and fer-ritin in diagnosing lung cancer.Methods The serum levels of NSE,CYFRA21-1,CEA,CA125,CA153 and ferritin were detected by the electrochemiluminescence method in 151 cases of lung cancer（lung cancer group）,100 cases of benign lung disease （benign dis-ease group）and 50 cases of healthy control group.The detection results were analyzed.Results The serum levels of NSE,CY-FRA21-1,CEA,CA125,CA153 and ferritin in the lung cancer group were significantly higher than those in the benign lung disease group and the healthy control group with statistical differences （P 〈0.05）;the NSE level in small cell lung cancer was higher than that in squamous carcinoma and adenocarcinoma with statistical difference（P 〈0.05）.The CYFRA21-1level in squamous carcinoma and adencarcinoma was higher than that in small cell lung cancer with statistical difference （P 〈0.05）.The sensitivity of NSE was highest in six tumor markers,which was 82.8%.In 6 tumor markers,3 markers were positive,the positive rate of lung cancer was higher,while the false positive rate was significantly reduced.Conclusion The levels and positive rates of serum tumor markers are associated with the pathological type of lung cancer.The combined detection of serum tumor markers can increase the sensitivity and accuracy in early diagnosis of lung cancer.The combination measurement of CEA,NSE and CYFRA21-1 is the first choice.

关 键 词：肿瘤标志物 肺癌 诊断价值 

分 类 号：R734.2[医药卫生—肿瘤]