Fas-1377基因多态与青海地区乳腺癌风险的关系  

Association between Fas-1377 gene polymorphisms and risk of breast cancer in Qinghai district

作　　者：胡英[1] 黄欣[1] 王秀娟[1] 金丽艳[2] 张双元[2] 

机构地区：[1]青海大学医学院,青海西宁810001 [2]青海大学附属医院,青海西宁810001

出　　处：《中国现代医学杂志》2014年第28期22-25,共4页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:30960359)

摘　　要：目的研究Fas-1377基因多态与青海地区乳腺癌风险的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析方法,检测了233例青海女性乳腺癌患者和219个正常女性的Fas-1377基因多态,用χ2检验分析其基因多态与乳腺癌风险间的关系。结果 233例乳腺癌中,Fas-1377基因多态频率分布:纯合野生型GG为21.0%(49/233)、杂合型GA为56.7%(132/233)、纯合突变型AA为22.3%(52/233)。正常对照组,219例正常女性中,Fas-1377基因多态频率分布:纯合野生型GG为36.6%(80/219)、杂合型GA为40.6%(89/219)、纯合突变型AA为22.8%(50/219)。青海地区乳腺癌病例组和正常对照组间Fas-1377基因多态分布差异有统计学意义(P=0.000)。结论 Fas-1377基因多态可能与青海地区乳腺癌风险有联系。【Objective】 To investigate the correlation between Fas-1377 gene polymorphisms and risk of breast cancer in Qinghai ,China. 【Methods】 The polymorphisms of Fas-1377 gene were detected by polymerase chain reaction-restriction fragment length polymorphisms assay （PCR-RFLP） in 233 female breast cancer patients and 219 normal female, X2 was applied to assess the association between polymorphisms of Fas-1377 gene and breast cancer risk. 【Results】 In 233 breast cancer patients, the frequency of Fas-1377 GG （homozygous wild type）, GA （heterozygous type）, AA （homozygous mutant type） was respectively 21.0% （49/233）, 56.7% （132/233） and 22.3% （52/233）. In the control group, the frequency of Fas-1377GG, GA, AA was respectively 36.6%（80/219）, 40.6% （89/219） and 22.8% （50/219） in 219 normal female. Significant difference existed in the distribution of Fas-1377 gene polymorphisms between breast cancer patients and normal controls （P =0.000）. 【Conclusions】 The polymorphisms of Fas- 1377 gene may be associated with risk of breast cancer in Qinghai ,China.

关 键 词：Fas-1377 基因多态 乳腺癌 风险 

分 类 号：R737.9[医药卫生—肿瘤]