短暂后循环缺血患者脑白质变性严重程度的相关因素分析  

Analysis of correlative factors of leukoaraiosis severity in transient posterior circulaton ischemia patients

作　　者：牛宝丰 周卫东 尹晓明 刘长春 郝丽梅 

机构地区：[1]煤炭总医院,北京100028

出　　处：《山东医药》2014年第40期16-18,21,共4页Shandong Medical Journal

基　　金：首都卫生发展科研专项资助项目(首发2011-6011-01)

摘　　要：目的分析短暂后循环缺血（PCI）患者脑白质变性（LA）严重程度的独立相关因素。方法连续选取313例短暂PCI患者,根据Wahlund改良LA分级量表（ARWMC）评分对LA严重程度的分级进行分组,记录各临床资料;对各计量资料与ARWMC评分进行Spearman相关分析,对各计数资料与ARWMC评分进行Kendall相关分析;对有统计意义的变量,进行有序多分类Logistic回归分析。结果各临床资料与LA得分的相关分析筛选结果显示,年龄、性别、心电图RV5＋SV2、颈动脉斑块、CRP、HDL、Hcy、叶酸与短暂PCI患者LA严重程度相关（P均〈0.1）;Logistic回归分析结果显示,未发现心电图RV5＋SV2、CRP、Hcy、性别与短暂PCI患者LA严重程度的独立相关性（P均〉0.05）;而年龄（P=0.000,OR=1.119,95%CI：1.089-1.149）、HDL（P=0.042,OR=0.390,95%CI：0.157-0.967）、叶酸（P=0.006,OR=0.914,95%CI：0.856-0.974）、颈动脉斑块形成（P=0.000,OR=5.023,95%CI：2.672-9.440）与短暂PCI患者LA严重程度独立相关（P均〈0.05）。结论年龄、有无颈动脉斑块及HDL、叶酸水平是短暂PCI患者LA严重程度的独立相关因素。Objective To explore the independent predictive factors of severity of leukoaraiosis（ LA） in transient posterior circulation ischemia（PCI） patients. Methods To select 313 consecutive PCI in patients with MRI images retrospectively,gathering their age,gender,ECG（ RV5＋ SV2）,plaques shown in carotid ultrasound,CRP,Cholesterol,HDL,Hcy,triglycerides,LDL,UA,HbA1 C,folic acid,VB12. The severity of LA was evaluated by ARWMC scale. Correlation analysis and ordinal logistic regression were analyzed with SPSS16. 0 software. Results Age,gender,ECG（RV5＋ SV2）,carotid plaque,CRP,HDL,Hcy,folic acid were screened out with correlation analysis（all P〈0.1）; the ordinal logistic regression indicated that age,HDL,folic acid carotid plaque were independent predictive factors of severity of LA in transient PCI patients（all P〈0. 05）. Conclusion Age,HDL,folic acid,carotid plaque are independent predictive factors of severity of LA in transient PCI patients.

关 键 词：短暂脑缺血 后循环 脑白质变性 相关因素 回归分析 

分 类 号：R743.9[医药卫生—神经病学与精神病学]